Bio

Honors & Awards


  • Pfizer Research Award, Pfizer (Feb. 2011)
  • Post-doctoral fellowship for perspective researchers, Swiss National Fonds (Feb. 2011)
  • NCCBI - Fellowship in Imaging Technology for Biology and Medicine, ETH and EPFL (Aug. 2008)
  • PhD training fellowship (Forschungskredit), University of Zurich (Jan. 2008)

Professional Education


  • Doctor of Philosophy, Eidgenossische Technische Hochschule (ETH Zurich) (2010)
  • Diploma in Physics, University of Heidelberg, Biophysics/ Neuroscience (2006)
  • Intermediate Diploma in Physics, University of Kiel, Physics (2003)

Stanford Advisors


Research & Scholarship

Current Research and Scholarly Interests


Main interests: Information processing and storage in artificial and bilogical neuronal networks

My primary research focus is directed towards understanding the basis of information processing and memory formation in neuronal networks using experimental aproaches such as in vivo imaging as well as computational approaches including simulations artificial neuronal network classifiers.

Technical skills: Two-photon imaging, miniaturized fluorescence in vivo microscopy, microscopy development, electrophysiology (in vivo and in vitro), neuronal simulations, data anlysis (imaging and ephys), electrical circuit development

Non-technical skills: scientifc writing and editing, organization and management skills, IT competency

Teaching

Graduate and Fellowship Programs


Publications

Journal Articles


  • Visualizing mammalian brain area interactions by dual-axis two-photon calcium imaging NATURE NEUROSCIENCE Lecoq, J., Savall, J., Vucinic, D., Grewe, B. F., Kim, H., Li, T. Z., Kitch, L. J., Schnitzer, M. J. 2014; 17 (12): 1825-1829

    View details for DOI 10.1038/nn.3867

    View details for Web of Science ID 000345484000032

  • Two-photon optogenetic toolbox for fast inhibition, excitation and bistable modulation NATURE METHODS Prakash, R., Yizhar, O., Grewe, B., Ramakrishnan, C., Wang, N., Goshen, I., Packer, A. M., Peterka, D. S., Yuste, R., Schnitzer, M. J., Deisseroth, K. 2012; 9 (12): 1171-U132

    Abstract

    Optogenetics with microbial opsin genes has enabled high-speed control of genetically specified cell populations in intact tissue. However, it remains a challenge to independently control subsets of cells within the genetically targeted population. Although spatially precise excitation of target molecules can be achieved using two-photon laser-scanning microscopy (TPLSM) hardware, the integration of two-photon excitation with optogenetics has thus far required specialized equipment or scanning and has not yet been widely adopted. Here we take a complementary approach, developing opsins with custom kinetic, expression and spectral properties uniquely suited to scan times typical of the raster approach that is ubiquitous in TPLSMlaboratories. We use a range of culture, slice and mammalian in vivo preparations to demonstrate the versatility of this toolbox, and we quantitatively map parameter space for fast excitation, inhibition and bistable control. Together these advances may help enable broad adoption of integrated optogenetic and TPLSMtechnologies across experimental fields and systems.

    View details for DOI 10.1038/NMETH.2215

    View details for Web of Science ID 000312093500018

    View details for PubMedID 23169303

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