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Dose Escalation Study of OMP-54F28 in Combination With Paclitaxel and Carboplatin in Patients With Recurrent Platinum-Sensitive Ovarian Cancer

The purpose of this study is to test the safety of OMP-54F28 when combined with the chemotherapy drugs paclitaxel and carboplatin that are standard of care for ovarian cancer. The study is designed to test the safety of OMP-54F28 at different dose levels and the effects, both good and bad, that it has on ovarian cancer when combined with paclitaxel and carboplatin. Since OMP-54F28 has not been tested with paclitaxel and carboplatin in humans before, it is not known if it will provide any benefit and if it will cause harmful side effects.

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