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S1314, Co-expression Extrapolation (COXEN) Program to Predict Chemotherapy Response in Patients With Bladder Cancer

The primary focus of this study is to see if looking at tumor biomarkers using a program called "coexpression extrapolation or COXEN" may predict response to chemotherapy before surgery. The COXEN program will not select the therapy, but the type of chemotherapy that patients receive will be randomly decided. Researchers will look at information collected and outcomes for all study participants to see how COXEN relates to how participants responded to chemotherapy. Other potential tests to predict a patient's response to chemotherapy will also be evaluated.

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