Cancer Institute A national cancer institute
designated cancer center

Major Areas of Research


Prostate Cancer

A major focus of Population Sciences research is identifying the genetic role in prostate cancer occurrence. To date, chromosomes 19p and 5q have been implicated. Further work is underway to narrow the regions on these chromosomes by tripling the number of markers and perform linkage analysis to exclude subregions with low lod scores.

Researchers are also collaborating on multi-center studies to correlate increased prostate cancer risk with specific geographic areas, as well as biological factors such as the C-peptide/fructosamine ratio and levels of C-peptide and serum insulin.

Dr. John has conducted a population-based case-control study to study the etiology of advanced prostate cancer in 1100 African-American and white men. Among a range of risk factors, the strongest inverse associations emerged for high sun exposure in the presence of certain VDR variants (Cancer Res 65:5470, 2005) which is consistent with a previous publication that reported inverse associations with sun exposure indices assessed in the National Health and Nutrition Examination Survey (NHANES) Follow-up Study (J Steroid Biochem Mol Biol 89-90:549, 2004). Inverse associations were also found for large body size in youth (Am J Epidemiol 161:1107, 2005). Analyses are ongoing to examine advanced prostate cancer risk in relation to physical activity, adult body size and weight change, medical history, and medication use. Collaborations are ongoing with Dr. Sue Ingles at USC to study the role of genetic variants in AR and LOX genes. Dr. John is also participating in a multi-center collaboration of admixture mapping in African-Americans.
Dr. Whittemore is participating in Genome wide Association study to further examine strong evidence for the existence of prostate cancer susceptibility genes. The International Consortium for Prostate Cancer Genetics (ICPCG) is funded through a grant from the Epidemiology and Genetics Research Program (EGRP) of the NCI.


This document was last modified: Monday, 27-Jun-2011 13:29:25 PDT

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