Causes and Consequences of Cancer-associated Alterations in Global Gene Expression Programs
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Program researchers are working to identify the causes and consequences of changes in gene expression associated with different cancers and their subtypes.
By studying the fundamental mechanisms that promote the survival, proliferation and metastasis of cancer, researchers hope to identify new molecular targets for future anti-cancer therapies as well as novel diagnostic and prognostic markers that may help determine the best course of treatment for individual patients.
Areas under investigation include:
- The role of the human microbial ecosystem in cancer susceptibility
- In vivo activity of different proteases throughout all stages of tumorigenesis, including angiogenesis, tumor growth, metastasis and invasion
- The influence of wound healing and hypoxia on cancer progression
- Characterization of T-cells based on their antigen specificity and physiological activation in tumor immunology
- Heterogeneity of signaling and extracellular matrix molecules across different tissue microenvironments and their role in promoting specific cellular fates
- The molecular and regulatory properties of human cancer stem cells
- Role of fibroblasts and other mesenchymal cells in creating a molecular microenvironment conducive to the survival, proliferation and metastasis of cancer
- Post-transcriptional regulation in different cancers, including the translation, localization and decay of mRNA and the specific interactions of RNA-binding proteins with their targets
Program Researchers
Trial Administration