Cancer Institute A national cancer institute
designated cancer center

Lymphoma Pathogenesis

Using the tools of immunology and molecular biology, program members are defining the molecular mechanisms that drive cancer development. A key goal of this work is to understand the role of myc oncogenes, the Hepatitis C virus and the Epstein-Barr virus (EBV) in lymphomagenesis. Because these factors help drive lymphoma cells to proliferate, it is expected that therapies leading to their suppression or withdrawal will weaken or stop disease progression.

Researchers are also investigating how tumor and normal cells differ in their ability to respond to growth signals. Using the fluorescence activated cell sorter (FACS) to sort cancer and normal cells from human tissue samples, researchers are working to identify the molecular bases for these differences.

Dean Felsher, MD, PhD

Shoshana Levy, PhD

Garry Nolan, PhD

Rob Tibshirani, PhD

 

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