Cancer Institute A national cancer institute
designated cancer center

Mechanisms and Pathways of Oncogenesis

“Young” cells (right) are small and actively cycling. After several passages in culture, “old” cells acquire a characteristic morphology, they are permanently arrested in their cell cycle, they become large and flat, often have two nuclei, and express markers of stress (blue staining). Loss of the Rb cancer gene leads to reversal of this aging process, suggesting that aging and cancer are intimately linked at the molecular level.

 

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