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Quynh-Thu Le, MD

Academic Appointments

  • Katharine Dexter McCormick and Stanley McCormick Memorial Professor and Professor, by courtesy, of Otolaryngology-Head and Neck Surgery

Key Documents

Contact Information

  • Clinical Offices
    Radiation Therapy 875 Blake Wilbur Dr Clinic D Stanford, CA 94305
    Tel Work (650) 723-6171 Fax (650) 725-8231
  • Academic Offices
    Personal Information
    Tel (650) 498-5032
    Adminsitrative Contact
    Belinda Mah Executive Administrative Associate & Project Coordinator Tel Work 650-725-0203
    Not for medical emergencies or patient use

Professional Overview

Bio

Quynh-Thu Le, MD received both her medical school and radiation oncology training at the University of California, San Francisco (UCSF). She then joined the Stanford faculty in 1997. She became the Chair of the Stanford Radiation Oncology Department in September 2011. She also holds the Katharine Dexter McCormick & Stanley Memorial Professorship at Stanford University.

Her research focuses on translating laboratory findings to the clinic and vice versa in head and neck cancer (HNC), specifically in the area of tumor hypoxia and salivary gland stem cells. Her research is reflected in both her publications and grant funding. Hers was one of the first groups that identified circulating biomarkers for tumor hypoxia in HNC, leading to the application of some of these markers in clinical trials, testing hypoxia targeted strategies. On the clinical side, she has led multicenter phase II and III clinical trials, testing the addition of novel drugs as either radiosensitizer or radioprotector with chemoradiotherapy in HNC. She has received grant support from the American Society of Clinical Oncology (ASCO), the American Society of Therapeutic Radiology and Oncology (ASTRO) Education & Development Award, R01 and R21 grants from the National Institute of Health (NIH). She was inducted into the Fellowship of the American College of Radiology (FACR) and the Institute of Medicine (IOM).

Administratively, she is the Co-Director of the Radiation Biology Program of the Stanford Cancer Institute and is the current Chair of the ASTRO Educational Committee. She is also the Chair of the Head and Neck Cancer Committee of the Radiation Therapy Oncology Group (RTOG), which is a NCI funded cooperative group, running large phase II-III studies for radiation in solid cancers. She serves on the editorial board of the several cancer related journals.

Clinical Focus

  • Head and Neck Cancer
  • Radiation Oncology
  • Lung Cancer - Radiation Oncology
  • Salivary Gland Tumors - Radiation Oncology
  • Head and Neck Cancers - Radiation Oncology
  • Larynx Cancer - Radiation Oncology
View All 9clinical focus of Quynh-Thu Le

Administrative Appointments

  • Co-Director, Radiation Biology Program, Stanford Cancer Institute (2004 - present)
  • Chair, Department of Radiation Oncology, Stanford University (2011 - present)
  • Director of Clinial research, Department of radiation oncology, stanford university (2005 - present)

Boards, Advisory Committees, Professional Organizations

  • Chair, Education Committee, ASTRO (2012 - present)
  • Treasurer and member of the Executive Committee, American Radium Socieity (2013 - present)
  • Chair, Head and Neck cancer Committee, NRG Oncology group (RTOG, NSABP & GOG) (2012 - present)

Professional Education

Internship: Highland General Hospital CA (1994)
Board Certification: Radiation Oncology, American Board of Radiology (1998)
Residency: UCSF Medical Center CA (1997)
Medical Education: UCSF School of Medicine CA (1993)
MD: UCSF, Medicine (1993)

Courses

2013-14

Postdoctoral Advisees

Jinnuo HanAdam Schmitt

Graduate and Fellowship Program Affiliations

Scientific Focus

Current Research and Scholarly Interests

My laboratory research interest focuses on the identification of biomarkers for prognosis in patients with head & neck or lung cancers. Current research goals are: to validate the prognostic significance of certain hypoxia markers using clinical samples from a randomized phase III clinical trial and to monitor the tumor burden of HPV-related head & neck cancers during therapy by tracking circulating HPV DNA in the blood. We are also looking to target Galectin-1 (an immunomodulator that is over expressed in many cancers and is associated with tumor aggressiveness) in combination with radiation in solid tumors, and to identify a microRNA signature in lung cancer. Additionally, we are working to isolate human salivary gland stem cells and to manipulate key molecular pathways involved in radiation injury of salivary glands in hopes of rescuing salivary gland function after head & neck radiation therapy.

I am also conducting a number of clinical trials specifically in patients with head and neck cancer. I chair the Head and Neck Cancer Committee of the NRG Oncology group, which is a cooperative group consisting of RTOG, NSABP and GO. I work with committee wit develop and conduct several large phase II and III trials to advance the clinical management of head and neck cancer in North American and hopefully to establish new standards of care in these cancers.

Publications

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Publication Topics

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