{"result":[{"lastName":"Hanawalt","clinicalFocus":[],"appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Professor,Dermatology"}],"primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=5957&type=small&showNoImage","displayName":"Philip C. Hanawalt","firstName":"Philip","href":"http://med.stanford.edu/profiles/cancer/researcher/Philip_Hanawalt","researchInterest":"Our current research focuses in two principal areas:\r\n\r\n1. The molecular basis for  diseases in which the pathway of transcription-coupled DNA repair is defective, including Cockyne syndrome (CS) and UV-sensitive syndrome (UVSS). Patients are severely sensitive to sunlight  but  get no cancers. See Hanawalt & Spivak, 2008, for review.\r\n\r\n2. Transcription arrest by guanine-rich DNA sequences and non-canonical secondary structures. Transcription collisions with replication forks."},{"lastName":"Chu","clinicalFocus":[{"focus":"Oncology"}],"appointments":[{"appointment":"Professor,Medicine - Oncology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Professor,Biochemistry"}],"primaryAppointment":"Professor,Medicine - Oncology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4149&type=small&showNoImage","displayName":"Gilbert Chu","firstName":"Gilbert","href":"http://med.stanford.edu/profiles/cancer/researcher/Gilbert_Chu","researchInterest":"Our laboratory focuses on understanding how cells respond to DNA damage. Our research currently involves areas that interact with each other: repair of radiation damage, and transcriptional responses to DNA damage."},{"lastName":"Cimprich","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Chemical and Systems Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Associate Professor (By courtesy),Natural Sciences Cluster - Chemistry"}],"primaryAppointment":"Associate Professor,Chemical and Systems Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4417&type=small&showNoImage","displayName":"Karlene Cimprich","firstName":"Karlene","href":"http://med.stanford.edu/profiles/cancer/researcher/Karlene_Cimprich","researchInterest":"The use of genetic, biochemical and chemical approaches to understand the DNA damage-induced cell cycle checkpoints and the processes that contribute to maintenance of genomic stability."},{"lastName":"Lin","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Chemical and Systems Biology"}],"primaryAppointment":"Postdoctoral Research fellow, Chemical and Systems Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=19977&type=small&showNoImage","displayName":"Jia-Ren Lin","firstName":"Jia-Ren","href":"http://med.stanford.edu/profiles/postdocs/researcher/Jia-Ren_Lin","researchInterest":""},{"lastName":"Smith","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Radiation Oncology"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Radiation Oncology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=7014&type=small&showNoImage","displayName":"Kendric C. Smith","firstName":"Kendric","href":"http://med.stanford.edu/profiles/cancer/researcher/Kendric_Smith","researchInterest":"The photochemistry and radiation chemistry of DNA, the genetic control and biochemical bases of the multiple pathways of DNA repair, and the roles of DNA repair processes in radiation and spontaneous mutagenesis. Over 190 papers have been published on these and related topics."},{"lastName":"Morrison","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Assistant Professor,Biology (School of Humanities and Sciences)","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=14873&type=small&showNoImage","displayName":"Ashby Morrison","firstName":"Ashby","href":"http://med.stanford.edu/profiles/cancer/researcher/Ashby_Morrison","researchInterest":"Our research interests are to elucidate the contribution of chromatin to mechanisms that promote genomic integrity."},{"lastName":"Driscoll","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Chemical and Systems Biology"}],"primaryAppointment":"Postdoctoral Research fellow, Chemical and Systems Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=8819&type=small&showNoImage","displayName":"Robert Driscoll","firstName":"Robert","href":"http://med.stanford.edu/profiles/postdocs/researcher/Robert_Driscoll","researchInterest":""},{"lastName":"Brown","clinicalFocus":[],"appointments":[{"appointment":"Professor,Radiation Oncology - Radiation and Cancer Biology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor,Radiation Oncology - Radiation and Cancer Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4536&type=small&showNoImage","displayName":"Martin Brown","firstName":"Martin","href":"http://med.stanford.edu/profiles/cancer/researcher/Martin_Brown","researchInterest":"We seek to understand the mechanisms responsible for the resistance of cancers to treatment and to develop strategies to overcome these resistances. We are using molecular and cellular techniques and mouse models to potentiate the activity of radiation on tumors by inhibiting the bone marrow rescue of the tumor vasculature following therapy."},{"lastName":"Ford","clinicalFocus":[{"focus":"Cancer Genetics"},{"focus":"Gastrointestinal Cancers - Genetics"},{"focus":"Gastrointestinal Cancers - Medical Oncology"},{"focus":"Breast Cancer - Genetics"},{"focus":"Ovarian Cancer - Genetics"},{"focus":"Medical Oncology"}],"appointments":[{"appointment":"Associate Professor,Medicine - Oncology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Associate Professor,Genetics"},{"appointment":"Associate Professor (By courtesy),Pediatrics"}],"primaryAppointment":"Associate Professor,Medicine - Oncology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4066&type=small&showNoImage","displayName":"James Ford","firstName":"James","href":"http://med.stanford.edu/profiles/cancer/researcher/James_Ford","researchInterest":"Mammalian DNA repair and DNA damage inducible responses; p53 tumor suppressor gene; transcription in nucleotide excision repair and mutagenesis; genetic determinants of cancer cell sensitivity to DNA\u000bdamage; genetics of inherited cancer susceptibility syndromes and human GI malignancies; clinical cancer genetics of BRCA1 and BRCA2 breast cancer and mismatch repair deficient colon cancer."},{"lastName":"Chung","clinicalFocus":[],"appointments":[{"appointment":"Basic Life Science Research Associate,Obstetrics & Gynecology"}],"primaryAppointment":"Basic Life Science Research Associate,Obstetrics & Gynecology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=10387&type=small&showNoImage","displayName":"Young Min Chung","firstName":"Young Min","href":"http://cancer.stanford.edu/profiles/Young Min_Chung","researchInterest":""},{"lastName":"Hristov","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor - Med Center Line,Radiation Oncology - Radiation Physics"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Assistant Professor - Med Center Line,Radiation Oncology - Radiation Physics","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=8011&type=small&showNoImage","displayName":"Dimitre Hristov","firstName":"Dimitre","href":"http://med.stanford.edu/profiles/cancer/researcher/Dimitre_Hristov","researchInterest":"Development and integration of X-ray, MRI and US imaging technologies for radiation therapy guidance; Design of synergistic approaches to radiation therapy delivery; Treatment planning optimization and modeling."},{"lastName":"Wong","clinicalFocus":[{"focus":"Dermatology"},{"focus":"Skin Cancer"},{"focus":"Teledermatology"}],"appointments":[{"appointment":"Clinical Assistant Professor,Dermatology"}],"primaryAppointment":"Clinical Assistant Professor,Dermatology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=7991&type=small&showNoImage","displayName":"David J. Wong, M.D., Ph.D.","firstName":"David","href":"http://med.stanford.edu/profiles/cancer/researcher/David_Wong","researchInterest":"My research interest is focused on investigating the molecular networks that underlie cancer stem cells and designing therapies that selectively target these cells, thereby eliminating a cancer's potential for regrowth."},{"lastName":"Jarosz","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Chemical and Systems Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Assistant Professor,Developmental Biology"}],"primaryAppointment":"Assistant Professor,Chemical and Systems Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=33778&type=small&showNoImage","displayName":"Daniel Jarosz","firstName":"Daniel","href":"http://med.stanford.edu/profiles/cancer/researcher/Daniel_Jarosz","researchInterest":"Survival in changing environments requires the acquisition of new heritable traits. However, mechanisms that safeguard the fidelity of DNA replication often limit the source of such novelty to relatively modest changes in the genetic code. Thus, the acquisition of new forms and functions is thought to be driven by rare variants that occur at random, and are enriched during times of stress. We have begun to study an intriguing alternative hypothesis: that intrinsic links between protein folding "},{"lastName":"Giaccia","clinicalFocus":[],"appointments":[{"appointment":"Professor,Radiation Oncology - Radiation and Cancer Biology"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Professor (By courtesy),Obstetrics & Gynecology"},{"appointment":"Professor (By courtesy),Surgery"}],"primaryAppointment":"Professor,Radiation Oncology - Radiation and Cancer Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4141&type=small&showNoImage","displayName":"Amato J. Giaccia","firstName":"Amato","href":"http://med.stanford.edu/profiles/cancer/researcher/Amato_Giaccia","researchInterest":"During the last five years, we have identified several small molecules that kill VHL deficient renal cancer cells through a synthetic lethal screening approach. Another major interest of my laboratory is in identifying hypoxia-induced genes involved in invasion and metastases. We are also investigating how hypoxia regulates gene expression epigenetically."},{"lastName":"Alli","clinicalFocus":[],"appointments":[{"appointment":"Instructor,Medicine - Oncology"}],"primaryAppointment":"Instructor,Medicine - Oncology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=9711&type=small&showNoImage","displayName":"Elizabeth Alli","firstName":"Elizabeth","href":"http://med.stanford.edu/profiles/cancer/researcher/Elizabeth_Alli","researchInterest":"I am interested in identifying targeted therapies for triple-negative breast cancers and developing a novel strategy of biomarker-based chemoprevention for hereditary cancers that arise due to mutations in the Breast Cancer Susceptibility Gene 1 (BRCA1)."},{"lastName":"Newman","clinicalFocus":[{"focus":"Diagnostic Radiology"},{"focus":"Pediatric Radiology"}],"appointments":[{"appointment":"Professor - Med Center Line,Radiology - Pediatric Radiology"}],"primaryAppointment":"Professor - Med Center Line,Radiology - Pediatric Radiology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=7665&type=small&showNoImage","displayName":"Beverley Newman","firstName":"Beverley","href":"http://med.stanford.edu/profiles/cancer/researcher/Beverley_Newman","researchInterest":""},{"lastName":"Cheng","clinicalFocus":[],"appointments":[{"appointment":"Ph.D., Genetics"}],"primaryAppointment":"Ph.D., Genetics","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=19855&type=small&showNoImage","displayName":"Mei-Hsin Cheng","firstName":"Mei-Hsin","href":"http://med.stanford.edu/profiles/cancer/researcher/Mei-Hsin_Cheng","researchInterest":"Breast Cancer.  Epithelial to Mesenchymal Transition."},{"lastName":"Moore","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Neurobiology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Associate Professor,Neurobiology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=3946&type=small&showNoImage","displayName":"Tirin Moore","firstName":"Tirin","href":"http://med.stanford.edu/profiles/cancer/researcher/Tirin_Moore","researchInterest":"We study neural mechanisms of visual-motor integration and the neural basis of cognition (e.g. attention). We study the activity of single neurons in visual and motor structures within the brain, examine how perturbing that activity affects neurons in other brain structures, and also how it affects the perceptual and"},{"lastName":"Berg","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Biochemistry"},{"appointment":"Professor Emeritus,SoM Dean's Office Administrative Units - Dean's Office Operations"},{"appointment":"Professor Emeritus,Biochemistry"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Biochemistry","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=6263&type=small&showNoImage","displayName":"Paul Berg","firstName":"Paul","href":"http://med.stanford.edu/profiles/cancer/researcher/Paul_Berg","researchInterest":"For about 10 years until 2000, my lab's research activities were focused on the mechanism of recombinational repair of double-strand breaks in DNA. We focused our efforts on two model systems:  one involved the repair of restriction enzyme cleavages at specific mammalian chromosomal loci and the second explored the biochemical properties of purified yeast Rad51 protein, an essential catalyst for synapsing the broken ends of DNA with an intact homologue of that sequence.  We also explored the ro"},{"lastName":"Seita","clinicalFocus":[],"appointments":[{"appointment":"Instructor,Stem Cell - Stem Cell Biology and Regenerative Medicine Institute"}],"primaryAppointment":"Instructor,Stem Cell - Stem Cell Biology and Regenerative Medicine Institute","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=10040&type=small&showNoImage","displayName":"Jun Seita","firstName":"Jun","href":"http://med.stanford.edu/profiles/cancer/researcher/Jun_Seita","researchInterest":""},{"lastName":"Hu","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Obstetrics & Gynecology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Associate Professor,Obstetrics & Gynecology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=10405&type=small&showNoImage","displayName":"Mickey Hu","firstName":"Mickey","href":"http://med.stanford.edu/profiles/cancer/researcher/Mickey_Hu","researchInterest":""}]}