{"result":[{"lastName":"Gozani","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Associate Professor,Biology (School of Humanities and Sciences)","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=6423&type=small&showNoImage","displayName":"Or Gozani","firstName":"Or","href":"http://med.stanford.edu/profiles/cancer/researcher/Or_Gozani","researchInterest":"We study the molecular mechanisms by which chromatin-signaling networks effect nuclear and epigenetic programs, and how dysregulation of these pathways leads to disease.  Our work centers on the biology of lysine methylation, a principal chromatin-regulatory mechanism that directs epigenetic processes.  We study how lysine methylation events are generated, sensed, and transduced, and how these chemical marks integrate with other nuclear signaling systems to govern diverse cellular functions."},{"lastName":"Maures","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Genetics"}],"primaryAppointment":"Postdoctoral Research fellow, Genetics","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=13311&type=small&showNoImage","displayName":"Travis J. Maures","firstName":"Travis","href":"http://med.stanford.edu/profiles/postdocs/researcher/Travis_Maures","researchInterest":""},{"lastName":"Lim","clinicalFocus":[],"appointments":[{"appointment":"Ph.D., Dean's Office"}],"primaryAppointment":"Ph.D., Dean's Office","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=19512&type=small&showNoImage","displayName":"Jana Lim","firstName":"Jana","href":"http://med.stanford.edu/profiles/cancer/researcher/Jana_Lim","researchInterest":""},{"lastName":"Hu","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Obstetrics & Gynecology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Associate Professor,Obstetrics & Gynecology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=10405&type=small&showNoImage","displayName":"Mickey Hu","firstName":"Mickey","href":"http://med.stanford.edu/profiles/cancer/researcher/Mickey_Hu","researchInterest":""},{"lastName":"Mancini","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Genetics"}],"primaryAppointment":"Postdoctoral Research fellow, Genetics","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=18945&type=small&showNoImage","displayName":"Elena Mancini","firstName":"Elena","href":"http://med.stanford.edu/profiles/postdocs/researcher/Elena_Mancini","researchInterest":""},{"lastName":"Giaccia","clinicalFocus":[],"appointments":[{"appointment":"Professor,Radiation Oncology - Radiation and Cancer Biology"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Professor (By courtesy),Obstetrics & Gynecology"},{"appointment":"Professor (By courtesy),Surgery"}],"primaryAppointment":"Professor,Radiation Oncology - Radiation and Cancer Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4141&type=small&showNoImage","displayName":"Amato J. Giaccia","firstName":"Amato","href":"http://med.stanford.edu/profiles/cancer/researcher/Amato_Giaccia","researchInterest":"During the last five years, we have identified several small molecules that kill VHL deficient renal cancer cells through a synthetic lethal screening approach. Another major interest of my laboratory is in identifying hypoxia-induced genes involved in invasion and metastases. We are also investigating how hypoxia regulates gene expression epigenetically."},{"lastName":"Meyer","clinicalFocus":[],"appointments":[{"appointment":"Professor,Chemical and Systems Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Chemical and Systems Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4007&type=small&showNoImage","displayName":"Tobias Meyer","firstName":"Tobias","href":"http://med.stanford.edu/profiles/cancer/researcher/Tobias_Meyer","researchInterest":"CELLULAR INFORMATION PROCESSING  The main problem in signal transduction is to understand how different receptor-stimuli specifically control diverse cell functions. We are using automated microscopy, live-cell fluorescent biosensors and perturbations of predicted signaling proteins to systematically dissect signaling networks.  This allows us to identify signaling modules and to elucidate and ultimately model the flow of cellular information."},{"lastName":"Chua","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Medicine - Endocrinology, Gerontology, & Metabolism"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Associate Professor,Medicine - Endocrinology, Gerontology, & Metabolism","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=6623&type=small&showNoImage","displayName":"Katrin Chua","firstName":"Katrin","href":"http://med.stanford.edu/profiles/cancer/researcher/Katrin_Chua","researchInterest":"Our lab is interested in understanding molecular processes that underlie aging and age-associated pathologies in mammals.  We focus on a family of genes, the SIRTs, which regulate stress resistance and lifespan in lower organisms such as yeast, worms, and flies.  In mammals, we recently uncovered a number of ways in which SIRT factors may contribute to cellular and organismal aging by regulating resistance to various forms of stress.  We have now begun to characterize the molecular mechanisms b"},{"lastName":"Benayoun","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Genetics"}],"primaryAppointment":"Postdoctoral Research fellow, Genetics","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=21212&type=small&showNoImage","displayName":"Berenice Benayoun","firstName":"Berenice","href":"http://med.stanford.edu/profiles/postdocs/researcher/Berenice_Benayoun","researchInterest":""},{"lastName":"Boxer","clinicalFocus":[{"focus":"Hematology"},{"focus":"Multiple Myeloma"},{"focus":"Multiple Myeloma - Medical Oncology"},{"focus":"Plasmacytoma"},{"focus":"Plasmacytoma - Hematology"},{"focus":"Plasmacytoma - Medical Oncology"}],"appointments":[{"appointment":"Professor,Medicine - Hematology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor,Medicine - Hematology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4658&type=small&showNoImage","displayName":"Linda Boxer","firstName":"Linda","href":"http://med.stanford.edu/profiles/cancer/researcher/Linda_Boxer","researchInterest":"Regulation of expression of oncogenes in normal and malignant hematologic cells."},{"lastName":"Cleary","clinicalFocus":[],"appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Member,Child Health Research Institute"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Professor,Pediatrics"}],"primaryAppointment":"Professor,Pathology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4506&type=small&showNoImage","displayName":"Michael Cleary","firstName":"Michael","href":"http://med.stanford.edu/profiles/cancer/researcher/Michael_Cleary","researchInterest":"The role of oncoproteins in cancer and development; molecular and cellular biology of hematologic malignancies; targeted molecular therapies of cancer."},{"lastName":"Schvarzstein","clinicalFocus":[],"appointments":[{"appointment":"Basic Life Science Research Associate,Developmental Biology"}],"primaryAppointment":"Basic Life Science Research Associate,Developmental Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=9884&type=small&showNoImage","displayName":"Mara Schvarzstein","firstName":"Mara","href":"http://cancer.stanford.edu/profiles/Mara_Schvarzstein","researchInterest":""},{"lastName":"Chang","clinicalFocus":[{"focus":"Dermatology"},{"focus":"General Dermatology"}],"appointments":[{"appointment":"Professor,Dermatology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor,Dermatology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=6089&type=small&showNoImage","displayName":"Howard Y. Chang","firstName":"Howard","href":"http://med.stanford.edu/profiles/cancer/researcher/Howard_Chang","researchInterest":"Our research is focused on how the activities of hundreds or even thousands of genes (gene parties) are coordinated to achieve biological meaning. We have pioneered methods to predict, dissect, and control large-scale gene regulatory programs; these methods  have provided insights into human development, cancer, and aging."},{"lastName":"Rodgers","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Neurology & Neurological Sciences"}],"primaryAppointment":"Postdoctoral Research fellow, Neurology & Neurological Sciences","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=19007&type=small&showNoImage","displayName":"Joseph T. Rodgers","firstName":"Joseph","href":"http://med.stanford.edu/profiles/postdocs/researcher/Joseph_Rodgers","researchInterest":""},{"lastName":"Ferrell","clinicalFocus":[],"appointments":[{"appointment":"Professor,Chemical and Systems Biology"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Professor,Biochemistry"}],"primaryAppointment":"Professor,Chemical and Systems Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4656&type=small&showNoImage","displayName":"James Ferrell","firstName":"James","href":"http://med.stanford.edu/profiles/cancer/researcher/James_Ferrell","researchInterest":"My lab has two main goals: to understand mitotic regulation and to understand the systems-level logic of simple signaling circuits.  We often make use of Xenopus laevis oocytes, eggs, and cell-free extracts for both sorts of study.  We also carry out single-cell fluorescence imaging studies on mammalian cell lines.  Our experimental work is complemented by computational and theoretical studies aimed at identifying the design principles of regulatory circuits."},{"lastName":"Roth","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Chemical and Systems Biology"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Chemical and Systems Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4175&type=small&showNoImage","displayName":"Richard Roth","firstName":"Richard","href":"http://med.stanford.edu/profiles/cancer/researcher/Richard_Roth","researchInterest":"Insulin is one of the primary regulators of rapid anabolic responses in the body. Defects in the synthesis and/or ability of cells to respond to insulin results in the condition known as diabetes mellitus. To better design methods of treatment for this disorder, we have been focusing our research on how insulin elicits its various biological responses."},{"lastName":"Wysocka","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Chemical and Systems Biology"},{"appointment":"Associate Professor,Developmental Biology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Associate Professor,Chemical and Systems Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=7764&type=small&showNoImage","displayName":"Joanna Wysocka","firstName":"Joanna","href":"http://med.stanford.edu/profiles/cancer/researcher/Joanna_Wysocka","researchInterest":"Research in our lab focuses on mechanisms of epigenetic regulation in differentiation and development. In particular, we are studying the function of histone modifying enzymes in embryonic stem cell self-renewal and in early cell fate decisions. We are interested in the role of chromatin modifications in establishment and maintenance of gene expression patterns during normal and pathological development, and in nuclear reprogramming."},{"lastName":"Helms","clinicalFocus":[],"appointments":[{"appointment":"Professor,Surgery - Plastic & Reconstructive Surgery"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Surgery - Plastic & Reconstructive Surgery","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=6152&type=small&showNoImage","displayName":"Jill Helms","firstName":"Jill","href":"http://med.stanford.edu/profiles/cancer/researcher/Jill_Helms","researchInterest":"Dr. Helms' research interests center around regenerative medicine and craniofacial development."},{"lastName":"Gupta","clinicalFocus":[{"focus":"Dermatology"},{"focus":"Psoriasis"},{"focus":"Atopic Dermatitis"},{"focus":"Scleroderma, Localized"},{"focus":"Lupus Erythematosus, Cutaneous"},{"focus":"Lupus Erythematosus, Discoid"},{"focus":"Dermatomyositis"}],"appointments":[{"appointment":"Clinical Assistant Professor,Dermatology"}],"primaryAppointment":"Clinical Assistant Professor,Dermatology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=8514&type=small&showNoImage","displayName":"Rajnish Gupta","firstName":"Rajnish","href":"http://med.stanford.edu/profiles/cancer/researcher/Rajnish_Gupta","researchInterest":""},{"lastName":"Flynn","clinicalFocus":[],"appointments":[{"appointment":"MD Student, School of Medicine"},{"appointment":"Ph.D., Dean's Office"}],"primaryAppointment":"MD Student, School of Medicine","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=18677&type=small&showNoImage","displayName":"Ryan A Flynn","firstName":"Ryan","href":"http://med.stanford.edu/profiles/cancer/researcher/Ryan_Flynn","researchInterest":"I'm interested in how non-coding RNAs mediate epigenetic changes during embryonic and cancer development."},{"lastName":"Wang","clinicalFocus":[{"focus":"Dermatology"},{"focus":"Complex Medical Dermatology"},{"focus":"Inpatient Dermatology"},{"focus":"Psoriasis"},{"focus":"Pruritus (Itching)"},{"focus":"Neuropathic/Neurogenic Dermatosis"}],"appointments":[{"appointment":"Instructor,Dermatology"},{"appointment":"Postdoctoral Research fellow, Dermatology"}],"primaryAppointment":"Instructor,Dermatology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=18079&type=small&showNoImage","displayName":"Kevin Wang","firstName":"Kevin","href":"http://med.stanford.edu/profiles/cancer/researcher/Kevin_Wang","researchInterest":""},{"lastName":"Webb","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Genetics"}],"primaryAppointment":"Postdoctoral Research fellow, Genetics","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=9984&type=small&showNoImage","displayName":"Ashley Webb","firstName":"Ashley","href":"http://med.stanford.edu/profiles/postdocs/researcher/Ashley_Webb","researchInterest":"Stem cell function requires both the establishment and maintenance of particular epigenetic states. Perturbation of the epigenetic status of stem cells may compromise both self-renewal and multipotency. Work from our lab has identified the Forkhead family transcription factor, FoxO3, as a regulator of adult neural stem cell (NSCs) quiescence, which prevents the depletion of this population of cells. Along with recent evidence that Forkhead family members act as \u0091pioneer factors\u0092 in the opening "},{"lastName":"Kim","clinicalFocus":[],"appointments":[{"appointment":"Professor,Developmental Biology"},{"appointment":"Professor,Genetics"},{"appointment":"Professor (By courtesy),Chemical and Systems Biology"}],"primaryAppointment":"Professor,Developmental Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4167&type=small&showNoImage","displayName":"Stuart Kim","firstName":"Stuart","href":"http://med.stanford.edu/profiles/cancer/researcher/Stuart_Kim","researchInterest":"Mechanisms of Aging in C. elegans and humans."}]}