{"result":[{"lastName":"Giaccia","clinicalFocus":[],"appointments":[{"appointment":"Professor,Radiation Oncology - Radiation and Cancer Biology"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Professor (By courtesy),Obstetrics & Gynecology"},{"appointment":"Professor (By courtesy),Surgery"}],"primaryAppointment":"Professor,Radiation Oncology - Radiation and Cancer Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4141&type=small&showNoImage","displayName":"Amato J. Giaccia","firstName":"Amato","href":"http://med.stanford.edu/profiles/cancer/researcher/Amato_Giaccia","researchInterest":"During the last five years, we have identified several small molecules that kill VHL deficient renal cancer cells through a synthetic lethal screening approach. Another major interest of my laboratory is in identifying hypoxia-induced genes involved in invasion and metastases. We are also investigating how hypoxia regulates gene expression epigenetically."},{"lastName":"Hu","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Obstetrics & Gynecology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Associate Professor,Obstetrics & Gynecology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=10405&type=small&showNoImage","displayName":"Mickey Hu","firstName":"Mickey","href":"http://med.stanford.edu/profiles/cancer/researcher/Mickey_Hu","researchInterest":""},{"lastName":"Webb","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Genetics"}],"primaryAppointment":"Postdoctoral Research fellow, Genetics","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=9984&type=small&showNoImage","displayName":"Ashley Webb","firstName":"Ashley","href":"http://med.stanford.edu/profiles/postdocs/researcher/Ashley_Webb","researchInterest":"Stem cell function requires both the establishment and maintenance of particular epigenetic states. Perturbation of the epigenetic status of stem cells may compromise both self-renewal and multipotency. Work from our lab has identified the Forkhead family transcription factor, FoxO3, as a regulator of adult neural stem cell (NSCs) quiescence, which prevents the depletion of this population of cells. Along with recent evidence that Forkhead family members act as \u0091pioneer factors\u0092 in the opening "},{"lastName":"Brett","clinicalFocus":[],"appointments":[{"appointment":"MD Student, School of Medicine"},{"appointment":"Ph.D., Stem Cell"}],"primaryAppointment":"MD Student, School of Medicine","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=18662&type=small&showNoImage","displayName":"Jamie Brett","firstName":"Jamie","href":"http://med.stanford.edu/profiles/cancer/researcher/Jamie_Brett","researchInterest":"Aging, stem cells, DNA methylation"},{"lastName":"Solow-Cordero","clinicalFocus":[],"appointments":[{"appointment":"Director, HTBC,Chemical and Systems Biology"},{"appointment":"Science & Engineering Assoc,Chemical and Systems Biology"}],"primaryAppointment":"Director, HTBC,Chemical and Systems Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=27225&type=small&showNoImage","displayName":"David Solow-Cordero","firstName":"David","href":"http://cancer.stanford.edu/profiles/David_Solow-Cordero","researchInterest":""},{"lastName":"Brown","clinicalFocus":[],"appointments":[{"appointment":"Professor,Radiation Oncology - Radiation and Cancer Biology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor,Radiation Oncology - Radiation and Cancer Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4536&type=small&showNoImage","displayName":"Martin Brown","firstName":"Martin","href":"http://med.stanford.edu/profiles/cancer/researcher/Martin_Brown","researchInterest":"We seek to understand the mechanisms responsible for the resistance of cancers to treatment and to develop strategies to overcome these resistances. We are using molecular and cellular techniques and mouse models to potentiate the activity of radiation on tumors by inhibiting the bone marrow rescue of the tumor vasculature following therapy."},{"lastName":"Chung","clinicalFocus":[],"appointments":[{"appointment":"Basic Life Science Research Associate,Obstetrics & Gynecology"}],"primaryAppointment":"Basic Life Science Research Associate,Obstetrics & Gynecology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=10387&type=small&showNoImage","displayName":"Young Min Chung","firstName":"Young Min","href":"http://cancer.stanford.edu/profiles/Young Min_Chung","researchInterest":""},{"lastName":"Rankin","clinicalFocus":[],"appointments":[{"appointment":"Basic Life Science Research Associate,Radiation Oncology - Radiation and Cancer Biology"}],"primaryAppointment":"Basic Life Science Research Associate,Radiation Oncology - Radiation and Cancer Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=10065&type=small&showNoImage","displayName":"Erinn Rankin","firstName":"Erinn","href":"http://cancer.stanford.edu/profiles/Erinn_Rankin","researchInterest":""},{"lastName":"Wei","clinicalFocus":[{"focus":"Hematology/Oncology/Stem Cell Transplant,  Pediatric"},{"focus":"Pediatric Hematology-Oncology"}],"appointments":[{"appointment":"Instructor,Pediatrics - Hematology & Oncology"}],"primaryAppointment":"Instructor,Pediatrics - Hematology & Oncology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=8537&type=small&showNoImage","displayName":"Michael Wei, MD, PhD","firstName":"Michael","href":"http://med.stanford.edu/profiles/cancer/researcher/Michael_Wei","researchInterest":""},{"lastName":"Morgan","clinicalFocus":[],"appointments":[{"appointment":"MD Student, School of Medicine"}],"primaryAppointment":"MD Student, School of Medicine","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=20071&type=small&showNoImage","displayName":"Alexander A. Morgan","firstName":"Alexander","href":"http://med.stanford.edu/profiles/cancer/researcher/Alexander_Morgan","researchInterest":""},{"lastName":"Sunwoo","clinicalFocus":[{"focus":"Thyroid Neoplasms"},{"focus":"Melanoma"},{"focus":"Parathyroid Neoplasms"},{"focus":"Tongue Neoplasms"},{"focus":"Otolaryngology - Head & Neck Surgery (Ear, Nose and Throat)"},{"focus":"Otolaryngology"},{"focus":"Thyroid Nodule"},{"focus":"Parotid Neoplasms"},{"focus":"Tonsillar Neoplasms"},{"focus":"Pharynx Neoplasms"},{"focus":"Cancer of the Pharynx"},{"focus":"Cancer of the Larynx"},{"focus":"Cancer Stem Cells"},{"focus":"Cancer of Mouth"},{"focus":"Cancer of Neck"},{"focus":"Cancer of the Nasopharynx"},{"focus":"Cancer of Oropharnyx"},{"focus":"Cancer of the Parotid"},{"focus":"Cancer of the Salivary Gland"}],"appointments":[{"appointment":"Assistant Professor,Otolaryngology (Head and Neck Surgery)"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Assistant Professor,Otolaryngology (Head and Neck Surgery)","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=8588&type=small&showNoImage","displayName":"John B. Sunwoo","firstName":"John","href":"http://med.stanford.edu/profiles/cancer/researcher/John_Sunwoo","researchInterest":"My laboratory is focused on two primary areas of research: (1) the immune response to head and neck cancer and to a tumorigenic population of cells within these malignancies called cancer stem cells; (2) the developmental programs of a special lymphocyte population involved in innate immunity called natural killer (NK) cells."},{"lastName":"Boxer","clinicalFocus":[{"focus":"Hematology"},{"focus":"Multiple Myeloma"},{"focus":"Multiple Myeloma - Medical Oncology"},{"focus":"Plasmacytoma"},{"focus":"Plasmacytoma - Hematology"},{"focus":"Plasmacytoma - Medical Oncology"}],"appointments":[{"appointment":"Professor,Medicine - Hematology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor,Medicine - Hematology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4658&type=small&showNoImage","displayName":"Linda Boxer","firstName":"Linda","href":"http://med.stanford.edu/profiles/cancer/researcher/Linda_Boxer","researchInterest":"Regulation of expression of oncogenes in normal and malignant hematologic cells."},{"lastName":"Bouley","clinicalFocus":[],"appointments":[{"appointment":"Professor - Med Center Line,Comparative Medicine"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Professor - Med Center Line (By courtesy),Pathology"}],"primaryAppointment":"Professor - Med Center Line,Comparative Medicine","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4428&type=small&showNoImage","displayName":"Donna M. Bouley","firstName":"Donna","href":"http://med.stanford.edu/profiles/cancer/researcher/Donna_Bouley","researchInterest":"Research interests: ocular pathology, host-pathogen interactions in infectious disease, infectious disease in frogs, phenotypic characterization of tg and ko mice, histopathology of minimally-invasive radiological ablation techniques (focused ultrasound, cryoablation)."},{"lastName":"Tibshirani","clinicalFocus":[],"appointments":[{"appointment":"Professor,Health Research & Policy - Biostatistics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Professor,Natural Sciences Cluster - Statistics"}],"primaryAppointment":"Professor,Health Research & Policy - Biostatistics","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4688&type=small&showNoImage","displayName":"Robert Tibshirani","firstName":"Robert","href":"http://med.stanford.edu/profiles/cancer/researcher/Robert_Tibshirani","researchInterest":"My research is in applied statistics and biostatistics. I specialize in \u000bcomputer-intensive methods for regression and classification, bootstrap, cross-validation\u000band statistical inference, and signal and image analysis for medical diagnosis."},{"lastName":"Wong","clinicalFocus":[],"appointments":[{"appointment":"Professor,Neurosurgery"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor,Neurosurgery","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=7143&type=small&showNoImage","displayName":"Albert J. Wong, M.D.","firstName":"Albert","href":"http://med.stanford.edu/profiles/cancer/researcher/Albert_Wong","researchInterest":"Our goal is to define targets for cancer therapeutics by identifying alterations in signal transduction proteins. We first identified a naturally occurring  mutant EGF receptor (EGFRvIII) and then delineated its unique signal transduction pathway. This work led to the identification of Gab1 followed by the discovery that JNK is constitutively active in tumors. We intiated using altered proteins as the target for vaccination, where an EGFRvIII based vaccine appears to be highly effective."},{"lastName":"Meyer","clinicalFocus":[],"appointments":[{"appointment":"Professor,Chemical and Systems Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Chemical and Systems Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4007&type=small&showNoImage","displayName":"Tobias Meyer","firstName":"Tobias","href":"http://med.stanford.edu/profiles/cancer/researcher/Tobias_Meyer","researchInterest":"CELLULAR INFORMATION PROCESSING  The main problem in signal transduction is to understand how different receptor-stimuli specifically control diverse cell functions. We are using automated microscopy, live-cell fluorescent biosensors and perturbations of predicted signaling proteins to systematically dissect signaling networks.  This allows us to identify signaling modules and to elucidate and ultimately model the flow of cellular information."},{"lastName":"Butte","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Pediatrics - Systems Medicine"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Child Health Research Institute"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Associate Professor,Genetics"},{"appointment":"Associate Professor (By courtesy),Computer Science"},{"appointment":"Associate Professor (By courtesy),Medicine - Immunology & Rheumatology"}],"primaryAppointment":"Associate Professor,Pediatrics - Systems Medicine","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=6603&type=small&showNoImage","displayName":"Atul Butte","firstName":"Atul","href":"http://med.stanford.edu/profiles/cancer/researcher/Atul_Butte","researchInterest":"The Butte Lab at Stanford builds and applies tools that convert more than 300 billion points of molecular, clinical, and epidemiological data -- measured by researchers and clinicians over the past decade -- into diagnostics, therapeutics, and new insights into disease."},{"lastName":"Ferrell","clinicalFocus":[],"appointments":[{"appointment":"Professor,Chemical and Systems Biology"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Professor,Biochemistry"}],"primaryAppointment":"Professor,Chemical and Systems Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4656&type=small&showNoImage","displayName":"James Ferrell","firstName":"James","href":"http://med.stanford.edu/profiles/cancer/researcher/James_Ferrell","researchInterest":"My lab has two main goals: to understand mitotic regulation and to understand the systems-level logic of simple signaling circuits.  We often make use of Xenopus laevis oocytes, eggs, and cell-free extracts for both sorts of study.  We also carry out single-cell fluorescence imaging studies on mammalian cell lines.  Our experimental work is complemented by computational and theoretical studies aimed at identifying the design principles of regulatory circuits."},{"lastName":"Rosen","clinicalFocus":[{"focus":"Pulmonology (Lung) and Critical Care "},{"focus":"Pulmonary Disease"}],"appointments":[{"appointment":"Associate Professor,Medicine - Pulmonary & Critical Care Medicine"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Associate Professor,Medicine - Pulmonary & Critical Care Medicine","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4245&type=small&showNoImage","displayName":"Glenn Rosen","firstName":"Glenn","href":"http://med.stanford.edu/profiles/cancer/researcher/Glenn_Rosen","researchInterest":"Our laboratory examines apoptotic and cell cycle pathways in cancer and lung disease. We have identified a novel cell cycle protein which regulates cell cycle progression in immune cells and the lung.  We are also studying signaling pathways that regulate cancer cell growth and metastasis."},{"lastName":"Russell","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Medical fellow, Medicine"}],"primaryAppointment":"Postdoctoral Medical fellow, Medicine","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=23331&type=small&showNoImage","displayName":"Jeffrey Russell","firstName":"Jeffrey","href":"http://med.stanford.edu/profiles/postdocs/researcher/Jeffrey_Russell","researchInterest":""},{"lastName":"Palmer","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Neurosurgery"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Associate Professor,Neurosurgery","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=5930&type=small&showNoImage","displayName":"Theo Palmer","firstName":"Theo","href":"http://med.stanford.edu/profiles/cancer/researcher/Theo_Palmer","researchInterest":"For most areas of the mammalian brain, the production of new nerve cells or neurons is restricted to fetal development. However, there are exceptions to the rule. Some areas of the brain continue to make new neurons throughout life. This neurogenesis is mediated by neural stem cells and our research goals are to understand how stem cell activity and fate are controlled. Ultimately, we hope to harness the nascent potential of stem cells to treat neurological injury and disease."},{"lastName":"Cheng","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor (Research),Radiology - Diagnostic Radiology"}],"primaryAppointment":"Assistant Professor (Research),Radiology - Diagnostic Radiology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=8291&type=small&showNoImage","displayName":"Zhen Cheng","firstName":"Zhen","href":"http://med.stanford.edu/profiles/cancer/researcher/Zhen_Cheng","researchInterest":"To develop novel molecular imaging probes and techniques for non-invasively early detection of cancer using multimodality imaging technologies including PET, SPECT, MRI, optical imaging, etc."},{"lastName":"Yue","clinicalFocus":[{"focus":"Cardiovascular Disease"},{"focus":"Cardiovascular Medicine"}],"appointments":[],"imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=8441&type=small&showNoImage","displayName":"Patrick Yue","firstName":"Patrick","href":"http://stanfordhospital.org/profiles/cancer/physician/Patrick_Yue","researchInterest":"My primary research focus has been the mechanisms of insulin resistance and diabetes as they pertain to the heart.  I am particularly interested in the potential involvement of the recently discovered peptide hormone apelin.  Recent studies in my laboratory group have focused on apelin's role in promoting insulin sensitivity on the systemic, tissue-specific, and cellular level.  We are currently investigating apelin-mediated signaling events in insulin-sensitive and -resistant cardiac muscle."}]}