{"result":[{"lastName":"Kay","clinicalFocus":[],"appointments":[{"appointment":"Professor,Pediatrics - Human Gene Therapy"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Child Health Research Institute"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Professor,Genetics"}],"primaryAppointment":"Professor,Pediatrics - Human Gene Therapy","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4409&type=small&showNoImage","displayName":"Mark A. Kay, M.D., Ph.D.","firstName":"Mark","href":"http://med.stanford.edu/profiles/cancer/researcher/Mark_Kay","researchInterest":"Mark A. Kay, M.D., Ph.D. Director of the Program in Human Gene Therapy and Professor in the Departments of Pediatrics and Genetics.  Respected worldwide for his work in gene therapy for hemophilia, Dr. Kay and his laboratory focus on establishing the scientific principles and developing the technologies needed for achieving persistent and therapeutic levels of gene expression in vivo. The major disease models are hemophilia, hepatitis C, and hepatitis B viral infections."},{"lastName":"Einav","clinicalFocus":[{"focus":"Infectious Disease"}],"appointments":[{"appointment":"Assistant Professor,Medicine - Infectious Diseases"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Child Health Research Institute"},{"appointment":"Assistant Professor,Microbiology & Immunology"}],"primaryAppointment":"Assistant Professor,Medicine - Infectious Diseases","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=9992&type=small&showNoImage","displayName":"Shirit Einav","firstName":"Shirit","href":"http://med.stanford.edu/profiles/cancer/researcher/Shirit_Einav","researchInterest":"My lab focuses on better understanding virus-host protein-protein interactions. We combine novel proteomic approaches, including high-fidelity microfluidics platforms, with molecular virology, biochemical, and functional genomic approaches for identification of host partners conservatively required by various viruses and development of broad-spectrum antiviral strategies with a high genetic barrier for resistance. We focus on Flaviviridae (currently, hepatitis C (HCV) and dengue) as well as HIV"},{"lastName":"Fire","clinicalFocus":[],"appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Child Health Research Institute"},{"appointment":"Professor,Genetics"}],"primaryAppointment":"Professor,Pathology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=3989&type=small&showNoImage","displayName":"Andrew Fire","firstName":"Andrew","href":"http://med.stanford.edu/profiles/cancer/researcher/Andrew_Fire","researchInterest":"We study natural cellular mechanisms for adapting to genetic change. These include systems activated during normal development and those for detecting and responding to foreign or unwanted genetic activity. Underlying these studies are questions of how a cells can distinguish information as \"self\" versus \"nonself\" or \"wanted\" versus \"unwanted\"."},{"lastName":"Snyder","clinicalFocus":[],"appointments":[{"appointment":"Professor,Genetics"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Member,Child Health Research Institute"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Genetics","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=13465&type=small&showNoImage","displayName":"Michael Snyder","firstName":"Michael","href":"http://med.stanford.edu/profiles/cancer/researcher/Michael_Snyder","researchInterest":"We are presently in an omics revolution in which genomes and other omes can be readily characterized. Our laboratory uses a variety of approaches to analyze genomes and regulatory networks. Our research focuses on yeast, an ideal model organism ideally suited to genetic analysis, and humans.\r\n\r\n1) Transcriptomes\r\nTo annotate genomes, we developed RNA sequencing for annotation the yeast and human transcriptomes. We discovered that the eukaryotic transcriptome is much more complex than previously"},{"lastName":"Glenn","clinicalFocus":[{"focus":"Gastroenterology"}],"appointments":[{"appointment":"Associate Professor,Medicine - Gastroenterology & Hepatology"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Member,Bio-X"},{"appointment":"Associate Professor,Microbiology & Immunology"}],"primaryAppointment":"Associate Professor,Medicine - Gastroenterology & Hepatology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4576&type=small&showNoImage","displayName":"Jeffrey S.  Glenn, M.D., Ph.D.","firstName":"Jeffrey","href":"http://med.stanford.edu/profiles/cancer/researcher/Jeffrey_Glenn","researchInterest":"Dr. Glenn's primary interest is in molecular virology, with a strong emphasis on translating this knowledge into novel antiviral therapies. Other interests include exploitation of hepatic stem cells, engineered human liver tissues, and new biodefense antiviral strategies."},{"lastName":"Berg","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Biochemistry"},{"appointment":"Professor Emeritus,SoM Dean's Office Administrative Units - Dean's Office Operations"},{"appointment":"Professor Emeritus,Biochemistry"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Biochemistry","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=6263&type=small&showNoImage","displayName":"Paul Berg","firstName":"Paul","href":"http://med.stanford.edu/profiles/cancer/researcher/Paul_Berg","researchInterest":"For about 10 years until 2000, my lab's research activities were focused on the mechanism of recombinational repair of double-strand breaks in DNA. We focused our efforts on two model systems:  one involved the repair of restriction enzyme cleavages at specific mammalian chromosomal loci and the second explored the biochemical properties of purified yeast Rad51 protein, an essential catalyst for synapsing the broken ends of DNA with an intact homologue of that sequence.  We also explored the ro"},{"lastName":"Hu","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Obstetrics & Gynecology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Associate Professor,Obstetrics & Gynecology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=10405&type=small&showNoImage","displayName":"Mickey Hu","firstName":"Mickey","href":"http://med.stanford.edu/profiles/cancer/researcher/Mickey_Hu","researchInterest":""},{"lastName":"Mocarski","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Microbiology & Immunology"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Microbiology & Immunology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4146&type=small&showNoImage","displayName":"Edward Mocarski","firstName":"Edward","href":"http://med.stanford.edu/profiles/cancer/researcher/Edward_Mocarski","researchInterest":"My research interests focus on the biology and pathogenesis of cytomegalovirus (CMV), an opportunistic pathogen that causes significant disease worldwide. We developed global approaches and produced key insights into the areas of CMV gene regulation, DNA replication and packaging, maturation, impact on the host cell, disease pathogenesis, latency and reactivation, host cell signaling and chemokine system. These diverse findings address key aspects of the virus-host interaction."},{"lastName":"Hodges","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Pathology"}],"primaryAppointment":"Postdoctoral Research fellow, Pathology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=15813&type=small&showNoImage","displayName":"Courtney Hodges","firstName":"Hamilton Courtney","href":"http://med.stanford.edu/profiles/postdocs/researcher/Hamilton Courtney_Hodges","researchInterest":""},{"lastName":"Paulmurugan","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor (Research),Radiology - Diagnostic Radiology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Assistant Professor (Research),Radiology - Diagnostic Radiology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=14774&type=small&showNoImage","displayName":"Ramasamy Paulmurugan","firstName":"Ramasamy","href":"http://med.stanford.edu/profiles/cancer/researcher/Ramasamy_Paulmurugan","researchInterest":""},{"lastName":"Greenberg","clinicalFocus":[],"appointments":[{"appointment":"Professor,Medicine - Gastroenterology & Hepatology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Member,Child Health Research Institute"},{"appointment":"Professor,Microbiology & Immunology"}],"primaryAppointment":"Professor,Medicine - Gastroenterology & Hepatology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=3791&type=small&showNoImage","displayName":"Harry B Greenberg","firstName":"Harry","href":"http://med.stanford.edu/profiles/cancer/researcher/Harry_Greenberg","researchInterest":"Molecular mechanisms of pathogenesis; determinants of protective immunity; host range and tissue tropism in liver and GI tract pathogenic viruses and studies of vaccines in people."},{"lastName":"Lorch","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor (Research),Structural Biology"}],"primaryAppointment":"Associate Professor (Research),Structural Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4116&type=small&showNoImage","displayName":"Yahli Lorch","firstName":"Yahli","href":"http://med.stanford.edu/profiles/cancer/researcher/Yahli_Lorch","researchInterest":""},{"lastName":"Torres","clinicalFocus":[],"appointments":[{"appointment":"MS, Dean's Office"}],"primaryAppointment":"MS, Dean's Office","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=20431&type=small&showNoImage","displayName":"Marisa Torres","firstName":"Marisa","href":"http://med.stanford.edu/profiles/cancer/researcher/Marisa_Torres","researchInterest":"biodefense, pathogen, virulence, antibiotic resistance, detection, forensics"},{"lastName":"Baker","clinicalFocus":[],"appointments":[{"appointment":"Professor Emeritus,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor Emeritus,Biology (School of Humanities and Sciences)","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=6206&type=small&showNoImage","displayName":"Bruce Baker","firstName":"Bruce","href":"http://med.stanford.edu/profiles/cancer/researcher/Bruce_Baker","researchInterest":""},{"lastName":"Boxer","clinicalFocus":[{"focus":"Hematology"},{"focus":"Multiple Myeloma"},{"focus":"Multiple Myeloma - Medical Oncology"},{"focus":"Plasmacytoma"},{"focus":"Plasmacytoma - Hematology"},{"focus":"Plasmacytoma - Medical Oncology"}],"appointments":[{"appointment":"Professor,Medicine - Hematology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor,Medicine - Hematology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4658&type=small&showNoImage","displayName":"Linda Boxer","firstName":"Linda","href":"http://med.stanford.edu/profiles/cancer/researcher/Linda_Boxer","researchInterest":"Regulation of expression of oncogenes in normal and malignant hematologic cells."},{"lastName":"Livingston","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)"}],"primaryAppointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=18838&type=small&showNoImage","displayName":"Christine Livingston","firstName":"Christine","href":"http://med.stanford.edu/profiles/postdocs/researcher/Christine_Livingston","researchInterest":"protein quality control \r\nubiquitin-proteasome system\r\nprotein misfolding in cancer"},{"lastName":"Puglisi","clinicalFocus":[],"appointments":[{"appointment":"Professor,Structural Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Structural Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4431&type=small&showNoImage","displayName":"Joseph (Jody) Puglisi","firstName":"Joseph","href":"http://med.stanford.edu/profiles/cancer/researcher/Joseph_Puglisi","researchInterest":"The Puglisi group investigates the role of RNA in cellular processes and disease.  We investigate dynamics using single-molecule approaches.  Our goal is a unified picture of structure, dynamics and function.  We are currently focused on the mechanism and regulation of translation, and the role of RNA in viral infections.  A long-term goal is to target processes involving RNA with novel therapeutic strategies."},{"lastName":"Chu","clinicalFocus":[{"focus":"Oncology"}],"appointments":[{"appointment":"Professor,Medicine - Oncology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Professor,Biochemistry"}],"primaryAppointment":"Professor,Medicine - Oncology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4149&type=small&showNoImage","displayName":"Gilbert Chu","firstName":"Gilbert","href":"http://med.stanford.edu/profiles/cancer/researcher/Gilbert_Chu","researchInterest":"Our laboratory focuses on understanding how cells respond to DNA damage. Our research currently involves areas that interact with each other: repair of radiation damage, and transcriptional responses to DNA damage."},{"lastName":"Pringle","clinicalFocus":[],"appointments":[{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Genetics","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=7022&type=small&showNoImage","displayName":"John R. Pringle","firstName":"John","href":"http://med.stanford.edu/profiles/cancer/researcher/John_Pringle","researchInterest":"Much of our research exploits the power of yeast as an experimentally tractable model eukaryote to investigate fundamental problems in cell and developmental biology such as the mechanisms of cell polarization and cytokinesis.  In another project, we are developing the small sea anemone Aiptasia as a model system for study of the molecular and cellular biology of dinoflagellate-cnidarian symbiosis, which is critical for the survival of most corals but still very poorly understood."},{"lastName":"Gehrke","clinicalFocus":[],"appointments":[{"appointment":"Basic Life Science Research Associate,Pathology"}],"primaryAppointment":"Basic Life Science Research Associate,Pathology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=9160&type=small&showNoImage","displayName":"Stephan Gehrke","firstName":"Stephan","href":"http://cancer.stanford.edu/profiles/Stephan_Gehrke","researchInterest":""}]}