{"result":[{"lastName":"Samos","clinicalFocus":[],"appointments":[{"appointment":"Science Writer/Editor,Neurosurgery"},{"appointment":"Information Editor,Neurosurgery"}],"primaryAppointment":"Science Writer/Editor,Neurosurgery","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=28093&type=small&showNoImage","displayName":"Cynthia Samos","firstName":"Cynthia","href":"http://cancer.stanford.edu/profiles/Cynthia_Samos","researchInterest":""},{"lastName":"Krasnow","clinicalFocus":[],"appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor,Biochemistry","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4120&type=small&showNoImage","displayName":"Mark Krasnow","firstName":"Mark","href":"http://med.stanford.edu/profiles/cancer/researcher/Mark_Krasnow","researchInterest":"-  Lung development and stem cells\r\n-  Neural control of breathing\r\n-  Lung diseases including lung cancer\r\n-  New genetic model organisms for medicine"},{"lastName":"Nusse","clinicalFocus":[],"appointments":[{"appointment":"Professor,Developmental Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor,Developmental Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4280&type=small&showNoImage","displayName":"Roeland Nusse","firstName":"Roeland","href":"http://med.stanford.edu/profiles/cancer/researcher/Roeland_Nusse","researchInterest":"Our laboratory studies Wnt signaling in development and disease. We found recently that Wnt proteins are unusual growth factors, because they are lipid-modified. We discovered that Wnt proteins promote the proliferation of stem cells of various origins. Current work is directed at understanding the function of the lipid on the Wnt,  using Wnt proteins as factors the expand stem cells and on understanding Wnt signaling during repair and regeneration after tissue injury."},{"lastName":"Lu","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Pathology"}],"primaryAppointment":"Associate Professor,Pathology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=3976&type=small&showNoImage","displayName":"Bingwei Lu","firstName":"Bingwei","href":"http://med.stanford.edu/profiles/cancer/researcher/Bingwei_Lu","researchInterest":"We are interested in understanding how neural stem cells balance their self-renewal and differentiation and how deregulation of this process can result in brain tumor. We are also interested in mechanisms of neurodegeneration in Alzheimer\u0092s and Parkinson\u0092s diseases. We are using both Drosophila and mammalian models to address these fundamental questions."},{"lastName":"Pringle","clinicalFocus":[],"appointments":[{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Genetics","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=7022&type=small&showNoImage","displayName":"John R. Pringle","firstName":"John","href":"http://med.stanford.edu/profiles/cancer/researcher/John_Pringle","researchInterest":"Much of our research exploits the power of yeast as an experimentally tractable model eukaryote to investigate fundamental problems in cell and developmental biology such as the mechanisms of cell polarization and cytokinesis.  In another project, we are developing the small sea anemone Aiptasia as a model system for study of the molecular and cellular biology of dinoflagellate-cnidarian symbiosis, which is critical for the survival of most corals but still very poorly understood."},{"lastName":"Hu","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Obstetrics & Gynecology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Associate Professor,Obstetrics & Gynecology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=10405&type=small&showNoImage","displayName":"Mickey Hu","firstName":"Mickey","href":"http://med.stanford.edu/profiles/cancer/researcher/Mickey_Hu","researchInterest":""},{"lastName":"Baker","clinicalFocus":[],"appointments":[{"appointment":"Professor Emeritus,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor Emeritus,Biology (School of Humanities and Sciences)","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=6206&type=small&showNoImage","displayName":"Bruce Baker","firstName":"Bruce","href":"http://med.stanford.edu/profiles/cancer/researcher/Bruce_Baker","researchInterest":""},{"lastName":"Chen","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Chemical and Systems Biology"},{"appointment":"Member,Child Health Research Institute"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Member,Bio-X"},{"appointment":"Associate Professor,Developmental Biology"},{"appointment":"Associate Professor (By courtesy),Natural Sciences Cluster - Chemistry Department"}],"primaryAppointment":"Associate Professor,Chemical and Systems Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=3938&type=small&showNoImage","displayName":"James K. Chen","firstName":"James","href":"http://med.stanford.edu/profiles/cancer/researcher/James_Chen","researchInterest":"Our laboratory combines synthetic chemistry and developmental biology to investigate the molecular events that regulate embryonic patterning, tissue regeneration, and tumorigenesis.  We are currently using genetic and small-molecule approaches to study the molecular mechanisms of Hedgehog signaling, and we are developing chemical technologies to perturb and observe the genetic programs that underlie vertebrate development."},{"lastName":"Ruiz-Lozano","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor (Research),Pediatrics - Cardiology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Child Health Research Institute"}],"primaryAppointment":"Associate Professor (Research),Pediatrics - Cardiology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=18359&type=small&showNoImage","displayName":"Pilar Ruiz-Lozano, Ph.D.","firstName":"Pilar","href":"http://med.stanford.edu/profiles/cancer/researcher/Pilar_Ruiz-Lozano","researchInterest":"Cardiac development and repair"},{"lastName":"Meyer","clinicalFocus":[],"appointments":[{"appointment":"Professor,Chemical and Systems Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Chemical and Systems Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4007&type=small&showNoImage","displayName":"Tobias Meyer","firstName":"Tobias","href":"http://med.stanford.edu/profiles/cancer/researcher/Tobias_Meyer","researchInterest":"CELLULAR INFORMATION PROCESSING  The main problem in signal transduction is to understand how different receptor-stimuli specifically control diverse cell functions. We are using automated microscopy, live-cell fluorescent biosensors and perturbations of predicted signaling proteins to systematically dissect signaling networks.  This allows us to identify signaling modules and to elucidate and ultimately model the flow of cellular information."},{"lastName":"Chai","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Otolaryngology (Head and Neck Surgery)"}],"primaryAppointment":"Postdoctoral Research fellow, Otolaryngology (Head and Neck Surgery)","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=13792&type=small&showNoImage","displayName":"Renjie Chai","firstName":"Renjie","href":"http://med.stanford.edu/profiles/postdocs/researcher/Renjie_Chai","researchInterest":""},{"lastName":"Rothenberg","clinicalFocus":[{"focus":"Gastroenterology"}],"appointments":[{"appointment":"Clinical Instructor,Medicine - Gastroenterology & Hepatology"},{"appointment":"Postdoctoral Research fellow, Medicine"}],"primaryAppointment":"Clinical Instructor,Medicine - Gastroenterology & Hepatology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=10397&type=small&showNoImage","displayName":"Michael Rothenberg","firstName":"Michael","href":"http://med.stanford.edu/profiles/cancer/researcher/Michael_Rothenberg","researchInterest":""},{"lastName":"Gehrke","clinicalFocus":[],"appointments":[{"appointment":"Basic Life Science Research Associate,Pathology"}],"primaryAppointment":"Basic Life Science Research Associate,Pathology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=9160&type=small&showNoImage","displayName":"Stephan Gehrke","firstName":"Stephan","href":"http://cancer.stanford.edu/profiles/Stephan_Gehrke","researchInterest":""},{"lastName":"Nachury","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Molecular & Cellular Physiology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Assistant Professor,Molecular & Cellular Physiology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=8391&type=small&showNoImage","displayName":"Maxence Nachury","firstName":"Maxence","href":"http://med.stanford.edu/profiles/cancer/researcher/Maxence_Nachury","researchInterest":"We study the primary cilium, a once-obscure cellular organelle recently \"re-discovered\" for its role in a number of signaling pathways. Defects in cilium biogenesis lead to a variety of hereditary disorders characterized by retinal degeneration, kidney cysts and obesity. Our goal is  to characterize these disorders at the molecular and cellular levels to gain insight into the basic mechanisms of primary cilium biogenesis and to discover novel ciliary signaling pathways."},{"lastName":"Kuo","clinicalFocus":[{"focus":"Medical Oncology"}],"appointments":[{"appointment":"Professor,Medicine - Hematology"},{"appointment":"Member,Child Health Research Institute"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Member,Bio-X"},{"appointment":"Professor (By courtesy),Chemical and Systems Biology"}],"primaryAppointment":"Professor,Medicine - Hematology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=5906&type=small&showNoImage","displayName":"Calvin Kuo","firstName":"Calvin","href":"http://med.stanford.edu/profiles/cancer/researcher/Calvin_Kuo","researchInterest":"We explore angiogenesis, cancer genomics, intestinal stem cells, and hepatic glucose metabolism.  Angiogenesis projects include endothelial miRNA and GPCR ko mice, blood-brain barrier regulation, stroke therapeutics and anti-angiogenic cancer therapy.  Intestinal stem cell projects use primary intestinal culture and mouse genetics to study injury-inducible vs homeostatic stem cells.  We use primary organoid cultures of diverse tissues for oncogene functional screening and therapeutics discovery."},{"lastName":"Roth","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Chemical and Systems Biology"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Chemical and Systems Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4175&type=small&showNoImage","displayName":"Richard Roth","firstName":"Richard","href":"http://med.stanford.edu/profiles/cancer/researcher/Richard_Roth","researchInterest":"Insulin is one of the primary regulators of rapid anabolic responses in the body. Defects in the synthesis and/or ability of cells to respond to insulin results in the condition known as diabetes mellitus. To better design methods of treatment for this disorder, we have been focusing our research on how insulin elicits its various biological responses."},{"lastName":"Olivares","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Developmental Biology"}],"primaryAppointment":"Postdoctoral Research fellow, Developmental Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=18321&type=small&showNoImage","displayName":"Gonzalo Olivares","firstName":"Gonzalo","href":"http://med.stanford.edu/profiles/postdocs/researcher/Gonzalo_Olivares","researchInterest":"Stem cells are unique in that can renew themselves through cell division or differentiate into a diverse range of specialized cell types.  I will study genes that functions to prevent the growth of tumors and regulates stem cell decisions. Understanding the molecular mechanisms that mediate the choice between self-renewal and differentiation in stem cells has important implications for many areas of biology, including ancer treatment, regenerative medicine and new cell-based therapies."},{"lastName":"Luo","clinicalFocus":[],"appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=6229&type=small&showNoImage","displayName":"Liqun Luo","firstName":"Liqun","href":"http://med.stanford.edu/profiles/cancer/researcher/Liqun_Luo","researchInterest":"We are studying how neural circuits are assembled during development, and how they contribute to sensory perception.  We are addressing these questions at different levels from molecular, cellular, circuit to animal behavior.  We are primarily using Drosophila as a model organism for our studies.  Most recently, we are also developing novel genetic tools in the mouse to extend our studies to the mammalian brain."},{"lastName":"Breslow","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Molecular & Cellular Physiology"}],"primaryAppointment":"Postdoctoral Research fellow, Molecular & Cellular Physiology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=19226&type=small&showNoImage","displayName":"David Breslow","firstName":"David","href":"http://med.stanford.edu/profiles/postdocs/researcher/David_Breslow","researchInterest":""}]}