{"result":[{"lastName":"Monack","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Microbiology & Immunology"},{"appointment":"Member,Child Health Research Institute"}],"primaryAppointment":"Associate Professor,Microbiology & Immunology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=8324&type=small&showNoImage","displayName":"Denise M. Monack","firstName":"Denise","href":"http://med.stanford.edu/profiles/cancer/researcher/Denise_Monack","researchInterest":"The primary focus of my research is to understand the genetic and molecular mechanisms of intracellular bacterial pathogenesis.  We use two model systems, Salmonella typhimurium and Francisella tularensis, to study the complex host-pathogen interactions.  Ultimately we would like to understand how Salmonella persists within certain hosts for years in the face of a robust immune response and how F. tularensis, a stealth invader, can cause a rapid, lethal infection."},{"lastName":"Huang","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Microbiology & Immunology"}],"primaryAppointment":"Postdoctoral Research fellow, Microbiology & Immunology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=13753&type=small&showNoImage","displayName":"Jun Huang","firstName":"Jun","href":"http://med.stanford.edu/profiles/postdocs/researcher/Jun_Huang","researchInterest":""},{"lastName":"Parnes","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Medicine - Immunology & Rheumatology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Medicine - Immunology & Rheumatology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4487&type=small&showNoImage","displayName":"Jane Parnes","firstName":"Jane","href":"http://med.stanford.edu/profiles/cancer/researcher/Jane_Parnes","researchInterest":"The lab is studying the mechanisms controlling B cell responsiveness and the balance between tolerance and autoimmunity.  B cells deficient in CD72 are hyperresponsive to stimulation through the B cell receptor.  We are examining the alterations in B cell signaling in these B cells and the mechanisms by which CD72 deficiency partially abrogates anergic tolerance.  We hope to learn how deficiency in CD72 leads to spontaneous autoimmunity and increased susceptibility to induced autoimmune disease."},{"lastName":"Strober","clinicalFocus":[{"focus":"Immunology and Rheumatology"},{"focus":"Rheumatology"}],"appointments":[{"appointment":"Professor,Medicine - Immunology & Rheumatology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor,Medicine - Immunology & Rheumatology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4152&type=small&showNoImage","displayName":"Samuel Strober","firstName":"Samuel","href":"http://med.stanford.edu/profiles/cancer/researcher/Samuel_Strober","researchInterest":"Mechanisms of immune tolerance; regulatory processes in autoimmunity and transplantation and extrathymic T cell maturation."},{"lastName":"Michie","clinicalFocus":[{"focus":"Anatomic Pathology"},{"focus":"Pathology and Laboratory Medicine"}],"appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Pathology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4707&type=small&showNoImage","displayName":"Sara Michie","firstName":"Sara","href":"http://med.stanford.edu/profiles/cancer/researcher/Sara_Michie","researchInterest":"Lymphocyte/endothelial cell adhesion mechanisms involved in lymphocyte migration to sites of inflammation; regulation of expression of endothelial cell adhesion molecules."},{"lastName":"Davis","clinicalFocus":[],"appointments":[{"appointment":"Professor,Microbiology & Immunology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor,Microbiology & Immunology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4282&type=small&showNoImage","displayName":"Mark M. Davis","firstName":"Mark","href":"http://med.stanford.edu/profiles/cancer/researcher/Mark_Davis","researchInterest":"Molecular mechanisms of lymphocyte recognition and differentiation; molecular genetics and expression of T-cell receptor genes.  Dynamics and functionality of specific T cell populations in human cancer."},{"lastName":"Maecker","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor (Research),Microbiology & Immunology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Associate Professor (Research),Microbiology & Immunology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=25058&type=small&showNoImage","displayName":"Holden Maecker","firstName":"Holden","href":"http://med.stanford.edu/profiles/cancer/researcher/Holden_Maecker","researchInterest":"I'm interested in immune monitoring of T cell responses to chronic pathogens such as CMV, and the correlation of T cell response signatures with disease protection."},{"lastName":"Peltz","clinicalFocus":[],"appointments":[{"appointment":"Professor,Anesthesia"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Anesthesia","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=8527&type=small&showNoImage","displayName":"Gary Peltz","firstName":"Gary","href":"http://med.stanford.edu/profiles/cancer/researcher/Gary_Peltz","researchInterest":"The laboratory develops and uses state of the art genomic methods to identify genetic factors affecting disease susceptibility, and to translate these findings into new treatments. We have developed a more efficient method for performing mouse genetic analysis, which has been used to analyze the genetic basis for 16 different biomedical traits. We are developing novel methods, and have developed a novel experimental platform that replaces mouse liver with functioning human liver tissue."},{"lastName":"Lau","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Surgery"}],"primaryAppointment":"Postdoctoral Research fellow, Surgery","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=30657&type=small&showNoImage","displayName":"Audrey Lau","firstName":"Audrey","href":"http://med.stanford.edu/profiles/postdocs/researcher/Audrey_Lau","researchInterest":""},{"lastName":"Okada","clinicalFocus":[],"appointments":[{"appointment":"Instructor,Neurology & Neurological Sciences"}],"primaryAppointment":"Instructor,Neurology & Neurological Sciences","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=8191&type=small&showNoImage","displayName":"Ami Okada","firstName":"Ami","href":"http://med.stanford.edu/profiles/cancer/researcher/Ami_Okada","researchInterest":"Our interests are to understand the mechanism and control of signals that regulate proliferation and differentiation in adult tissue.  We are currently focused on studying modulation of the Hedgehog pathway in brain and muscle stem cell compartments during normal homeostasis and in degeneration or disease."},{"lastName":"Tato","clinicalFocus":[],"appointments":[{"appointment":"Research and Science Analyst,Institute for Immunity, Transplantaion and Infection"},{"appointment":"Acad Research & Pgrm Officer,Institute for Immunity, Transplantaion and Infection"}],"primaryAppointment":"Research and Science Analyst,Institute for Immunity, Transplantaion and Infection","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=25587&type=small&showNoImage","displayName":"Cristina M. Tato","firstName":"Cristina","href":"http://cancer.stanford.edu/profiles/Cristina_Tato","researchInterest":""},{"lastName":"Fathman","clinicalFocus":[{"focus":"Immunology"},{"focus":"Immunology and Rheumatology"}],"appointments":[{"appointment":"Professor,Medicine - Immunology & Rheumatology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor,Medicine - Immunology & Rheumatology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4479&type=small&showNoImage","displayName":"C. Garrison Fathman","firstName":"C","href":"http://med.stanford.edu/profiles/cancer/researcher/C_Fathman","researchInterest":"My lab of molecular and cellular immunology is interested in research in the general field of T cell activation and autoimmunity.   We use lentiviral mediated transduction of murine dendritic cells with immunoregulatory proteins for site specific and targeted immunotherapy. We have identified and characterized a gene (GRAIL) that seems to control T cell anergy.    We have recently characterized a gene (Deaf1) that seems to play a major role in peripheral tolerance in T1D."},{"lastName":"Shastri","clinicalFocus":[],"appointments":[{"appointment":"Ph.D., Dean's Office"}],"primaryAppointment":"Ph.D., Dean's Office","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=20089&type=small&showNoImage","displayName":"Anjali Shastri","firstName":"Anjali","href":"http://med.stanford.edu/profiles/cancer/researcher/Anjali_Shastri","researchInterest":""},{"lastName":"Dong","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Molecular & Cellular Physiology"}],"primaryAppointment":"Postdoctoral Research fellow, Molecular & Cellular Physiology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=25093&type=small&showNoImage","displayName":"Shen Dong","firstName":"Shen","href":"http://med.stanford.edu/profiles/postdocs/researcher/Shen_Dong","researchInterest":""},{"lastName":"Bonham","clinicalFocus":[{"focus":"General Surgery"},{"focus":"Liver Transplantation"},{"focus":"Live-donor Liver Transplantation"},{"focus":"Pediatric Transplantation"},{"focus":"Intestinal Transplantation"},{"focus":"Kidney and Pancreas Transplantation"},{"focus":"Portal Hypertension"},{"focus":"Hepatobiliary Surgery"},{"focus":"Cancer of Biliary Tract"},{"focus":"Cancer, Liver"}],"appointments":[{"appointment":"Associate Professor - Med Center Line,Surgery - Multi-Organ Transplantation"},{"appointment":"Member,Child Health Research Institute"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Associate Professor - Med Center Line,Surgery - Multi-Organ Transplantation","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=3884&type=small&showNoImage","displayName":"Clark Bonham","firstName":"Clark","href":"http://med.stanford.edu/profiles/cancer/researcher/Clark_Bonham","researchInterest":"Tolerance induction in liver transplantation.\r\nHepatocyte transplantation."},{"lastName":"Bollyky","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Medicine - Infectious Diseases"},{"appointment":"Member,Child Health Research Institute"}],"primaryAppointment":"Assistant Professor,Medicine - Infectious Diseases","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=35956&type=small&showNoImage","displayName":"Paul Bollyky","firstName":"Paul","href":"http://med.stanford.edu/profiles/cancer/researcher/Paul_Bollyky","researchInterest":"Our research is focused on the role of extracellular matrix (ECM) in inflammation and infection.    In particular, we study how the ECM in injured and healing tissues provides contextual cues that drive the behavior of regulatory T-cells and other leukocytes. Our goals are 1. to understand how the matrix contributes both to normal wound healing and to immune dysregulation, such as that seen in asthma and autoimmunity, and 2. to devise novel strategies and tools to promote immune tolerance."},{"lastName":"Yan","clinicalFocus":[],"appointments":[{"appointment":"Instructor,Medicine - Hematology"}],"primaryAppointment":"Instructor,Medicine - Hematology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=13412&type=small&showNoImage","displayName":"Kelley Yan","firstName":"Kelley","href":"http://med.stanford.edu/profiles/cancer/researcher/Kelley_Yan","researchInterest":""},{"lastName":"Rouse","clinicalFocus":[],"appointments":[{"appointment":"Professor - Med Center Line,Pathology"}],"primaryAppointment":"Professor - Med Center Line,Pathology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4491&type=small&showNoImage","displayName":"Robert V Rouse","firstName":"Robert","href":"http://med.stanford.edu/profiles/cancer/researcher/Robert_Rouse","researchInterest":"My recent research efforts are currently focused in the field of applications of immunohistology to the diagnosis of human neoplasms. This work is predominantly aimed at characterizing markers for the identification of non-lymphoid neoplasms and at establishing criteria for their evaluation in diagnostic situations."},{"lastName":"Kruse","clinicalFocus":[],"appointments":[{"appointment":"Ph.D., Structural Biology"}],"primaryAppointment":"Ph.D., Structural Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=20137&type=small&showNoImage","displayName":"Andrew Kruse","firstName":"Andrew","href":"http://med.stanford.edu/profiles/cancer/researcher/Andrew_Kruse","researchInterest":""},{"lastName":"Levitt","clinicalFocus":[],"appointments":[{"appointment":"Professor,Structural Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Professor (By courtesy),Computer Science"}],"primaryAppointment":"Professor,Structural Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4494&type=small&showNoImage","displayName":"Michael Levitt","firstName":"Michael","href":"http://med.stanford.edu/profiles/cancer/researcher/Michael_Levitt","researchInterest":"having pioneered, we (a) predict folding of a polypeptide and RNA chains into a unique native-structure, we (b) model protein structure using the well-established paradigms that similar protein sequences imply similar three-dimensional structures, and (c) we are focusing on mesoscale modeling of large macromolecular complexes such as RNA polymerase and the mammalian chaperonin."},{"lastName":"Chan","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Medical fellow, Medicine"}],"primaryAppointment":"Postdoctoral Medical fellow, Medicine","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=23335&type=small&showNoImage","displayName":"Steven Chan","firstName":"Steven","href":"http://med.stanford.edu/profiles/postdocs/researcher/Steven_Chan","researchInterest":""}]}