{"result":[{"lastName":"Yamazoe","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Chemical and Systems Biology"}],"primaryAppointment":"Postdoctoral Research fellow, Chemical and Systems Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=16859&type=small&showNoImage","displayName":"Sayumi Yamazoe","firstName":"Sayumi","href":"http://med.stanford.edu/profiles/postdocs/researcher/Sayumi_Yamazoe","researchInterest":""},{"lastName":"Rack","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Medicine"}],"primaryAppointment":"Postdoctoral Research fellow, Medicine","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=19586&type=small&showNoImage","displayName":"Paul G. Rack","firstName":"Paul","href":"http://med.stanford.edu/profiles/postdocs/researcher/Paul_Rack","researchInterest":""},{"lastName":"Rohatgi","clinicalFocus":[{"focus":"Medical Oncology"}],"appointments":[{"appointment":"Assistant Professor,Medicine - Oncology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Assistant Professor (By courtesy),Biochemistry"}],"primaryAppointment":"Assistant Professor,Medicine - Oncology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=10885&type=small&showNoImage","displayName":"Rajat Rohatgi","firstName":"Rajat","href":"http://med.stanford.edu/profiles/cancer/researcher/Rajat_Rohatgi","researchInterest":"We are working to elucidate the biochemical and cell biological principles that govern signaling pathways that sit at the intersection between developmental biology and cancer.  Our toolkit combines bulk biochemical techniques, such as cell-free reconstitution, with microscopy using novel optical probes to study the dynamics of signal propagation in cells.  We strive to develop novel strategies for the manipulation of these pathways for cancer therapies and applications in regenerative medicine."},{"lastName":"Cho","clinicalFocus":[{"focus":"Neurology - Child Neurology"},{"focus":"Neuro-oncology"}],"appointments":[{"appointment":"Assistant Professor - Med Center Line,Neurology & Neurological Sciences"},{"appointment":"Member,Child Health Research Institute"}],"primaryAppointment":"Assistant Professor - Med Center Line,Neurology & Neurological Sciences","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=24609&type=small&showNoImage","displayName":"Yoon-Jae Cho","firstName":"Yoon-Jae","href":"http://med.stanford.edu/profiles/cancer/researcher/Yoon-Jae_Cho","researchInterest":"My laboratory studies childhood brain tumors with a particular focus on medulloblastoma, the most common malignant brain tumor in children. We utilize both top-down and bottom-up strategies to understand the biology of these tumors and identify new therapeutic avenues to more effectively treat these diseases."},{"lastName":"Meyer","clinicalFocus":[],"appointments":[{"appointment":"Professor,Chemical and Systems Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Chemical and Systems Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4007&type=small&showNoImage","displayName":"Tobias Meyer","firstName":"Tobias","href":"http://med.stanford.edu/profiles/cancer/researcher/Tobias_Meyer","researchInterest":"CELLULAR INFORMATION PROCESSING  The main problem in signal transduction is to understand how different receptor-stimuli specifically control diverse cell functions. We are using automated microscopy, live-cell fluorescent biosensors and perturbations of predicted signaling proteins to systematically dissect signaling networks.  This allows us to identify signaling modules and to elucidate and ultimately model the flow of cellular information."},{"lastName":"Mourrain","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor (Research),Psychiatry & Behavioral Science - Sleep Center"}],"primaryAppointment":"Associate Professor (Research),Psychiatry & Behavioral Science - Sleep Center","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=24313&type=small&showNoImage","displayName":"Philippe Mourrain","firstName":"Philippe","href":"http://med.stanford.edu/profiles/cancer/researcher/Philippe_Mourrain","researchInterest":""},{"lastName":"Nachury","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Molecular & Cellular Physiology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Assistant Professor,Molecular & Cellular Physiology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=8391&type=small&showNoImage","displayName":"Maxence Nachury","firstName":"Maxence","href":"http://med.stanford.edu/profiles/cancer/researcher/Maxence_Nachury","researchInterest":"We study the primary cilium, a once-obscure cellular organelle recently \"re-discovered\" for its role in a number of signaling pathways. Defects in cilium biogenesis lead to a variety of hereditary disorders characterized by retinal degeneration, kidney cysts and obesity. Our goal is  to characterize these disorders at the molecular and cellular levels to gain insight into the basic mechanisms of primary cilium biogenesis and to discover novel ciliary signaling pathways."},{"lastName":"Teruel","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Chemical and Systems Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Assistant Professor,Chemical and Systems Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=14171&type=small&showNoImage","displayName":"Mary Frances Nunez Teruel","firstName":"Mary","href":"http://med.stanford.edu/profiles/cancer/researcher/Mary_Teruel","researchInterest":"The Teruel Lab uses a combination of engineering and biological approaches including high-throughput screening of RNAi and DNA construct libraries, targeted mass spectrometry, live-cell fluorescence microscopy, and bioinformatics to investigate the systems biology of cell differentiation and cell signaling with particular focus on uncovering the molecular mechanisms underlying insulin resistance, diabetes, and obesity."},{"lastName":"Yang","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Stem Cell"}],"primaryAppointment":"Postdoctoral Research fellow, Stem Cell","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=18228&type=small&showNoImage","displayName":"Nan Yang","firstName":"Nan","href":"http://med.stanford.edu/profiles/postdocs/researcher/Nan_Yang","researchInterest":""},{"lastName":"Helms","clinicalFocus":[],"appointments":[{"appointment":"Professor,Surgery - Plastic & Reconstructive Surgery"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Surgery - Plastic & Reconstructive Surgery","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=6152&type=small&showNoImage","displayName":"Jill Helms","firstName":"Jill","href":"http://med.stanford.edu/profiles/cancer/researcher/Jill_Helms","researchInterest":"Dr. Helms' research interests center around regenerative medicine and craniofacial development."},{"lastName":"Ouyang","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Chemical and Systems Biology"}],"primaryAppointment":"Postdoctoral Research fellow, Chemical and Systems Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=20219&type=small&showNoImage","displayName":"Xiaohu \"Shawn\" Ouyang","firstName":"Xiaohu","href":"http://med.stanford.edu/profiles/postdocs/researcher/Xiaohu_Ouyang","researchInterest":"Chemical Biology and Tissue Regeneration"},{"lastName":"Sage","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Pediatrics - Cancer Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Child Health Research Institute"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Associate Professor,Genetics"}],"primaryAppointment":"Associate Professor,Pediatrics - Cancer Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=6009&type=small&showNoImage","displayName":"Julien Sage","firstName":"Julien","href":"http://med.stanford.edu/profiles/cancer/researcher/Julien_Sage","researchInterest":"We are interested in the links between the basic cell cycle machinery and the factors controlling self-renewal, differentiation, and regeneration. In particular, we are intrigued by the differences and the similarities between \"normal\" cells, cancer cells, and stem cells. We investigate the mechanisms by which normal cells become tumor cells, and we aim to understand the differences between the proliferative response in response to injury and the hyperproliferative phenotype of cancer cells."},{"lastName":"Sweet-Cordero","clinicalFocus":[{"focus":"Pediatric Hematology-Oncology"},{"focus":"Ewing's sarcoma"},{"focus":"Osteosarcoma"}],"appointments":[{"appointment":"Associate Professor (Research),Pediatrics - Cancer Biology"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Child Health Research Institute"}],"primaryAppointment":"Associate Professor (Research),Pediatrics - Cancer Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=6970&type=small&showNoImage","displayName":"Alejandro Sweet-Cordero","firstName":"Alejandro","href":"http://med.stanford.edu/profiles/cancer/researcher/Alejandro_Sweet-Cordero","researchInterest":"Our laboratory is devoted to the analysis of pathways involved in the initiation, progression, and maintenance of cancer.   Utilizing the mouse as a model system, we strive to understand aberrant oncogenic signaling, the role of the tumor microenvironment and the mechanisms involved in chemotherapy response and resistance at the molecular, cellular, and organismal levels."},{"lastName":"Solow-Cordero","clinicalFocus":[],"appointments":[{"appointment":"Director, HTBC,Chemical and Systems Biology"},{"appointment":"Science & Engineering Assoc,Chemical and Systems Biology"}],"primaryAppointment":"Director, HTBC,Chemical and Systems Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=27225&type=small&showNoImage","displayName":"David Solow-Cordero","firstName":"David","href":"http://cancer.stanford.edu/profiles/David_Solow-Cordero","researchInterest":""},{"lastName":"Chang","clinicalFocus":[{"focus":"Dermatology"},{"focus":"General Dermatology"}],"appointments":[{"appointment":"Professor,Dermatology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor,Dermatology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=6089&type=small&showNoImage","displayName":"Howard Y. Chang","firstName":"Howard","href":"http://med.stanford.edu/profiles/cancer/researcher/Howard_Chang","researchInterest":"Our research is focused on how the activities of hundreds or even thousands of genes (gene parties) are coordinated to achieve biological meaning. We have pioneered methods to predict, dissect, and control large-scale gene regulatory programs; these methods  have provided insights into human development, cancer, and aging."},{"lastName":"Kosinski","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Medicine"}],"primaryAppointment":"Postdoctoral Research fellow, Medicine","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=17415&type=small&showNoImage","displayName":"Cynthia Kosinski","firstName":"Cynthia","href":"http://med.stanford.edu/profiles/postdocs/researcher/Cynthia_Kosinski","researchInterest":""},{"lastName":"Beachy","clinicalFocus":[],"appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Professor,Developmental Biology"}],"primaryAppointment":"Professor,Biochemistry","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=7655&type=small&showNoImage","displayName":"Philip Beachy","firstName":"Philip","href":"http://med.stanford.edu/profiles/cancer/researcher/Philip_Beachy","researchInterest":"Function of Hedgehog proteins and other extracellular signals in morphogenesis (pattern formation), in injury repair and regeneration (pattern maintenance). We study how the distribution of such signals is regulated in tissues, how cells perceive and respond to distinct concentrations of signals, and how such signaling pathways arose in evolution. We also study the normal roles of such signals in stem-cell physiology and their abnormal roles in the formation and expansion of cancer stem cells."},{"lastName":"Straight","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Biochemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Associate Professor,Biochemistry","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=6006&type=small&showNoImage","displayName":"Aaron Straight","firstName":"Aaron","href":"http://med.stanford.edu/profiles/cancer/researcher/Aaron_Straight","researchInterest":"We study the process of cell division. Our research is focused on understanding how chromosomes are segregated during mitosis and how cells divide during cytokinesis."},{"lastName":"Nusse","clinicalFocus":[],"appointments":[{"appointment":"Professor,Developmental Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor,Developmental Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=4280&type=small&showNoImage","displayName":"Roeland Nusse","firstName":"Roeland","href":"http://med.stanford.edu/profiles/cancer/researcher/Roeland_Nusse","researchInterest":"Our laboratory studies Wnt signaling in development and disease. We found recently that Wnt proteins are unusual growth factors, because they are lipid-modified. We discovered that Wnt proteins promote the proliferation of stem cells of various origins. Current work is directed at understanding the function of the lipid on the Wnt,  using Wnt proteins as factors the expand stem cells and on understanding Wnt signaling during repair and regeneration after tissue injury."},{"lastName":"Samos","clinicalFocus":[],"appointments":[{"appointment":"Science Writer/Editor,Neurosurgery"},{"appointment":"Information Editor,Neurosurgery"}],"primaryAppointment":"Science Writer/Editor,Neurosurgery","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=28093&type=small&showNoImage","displayName":"Cynthia Samos","firstName":"Cynthia","href":"http://cancer.stanford.edu/profiles/Cynthia_Samos","researchInterest":""},{"lastName":"Ge","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Developmental Biology"}],"primaryAppointment":"Postdoctoral Research fellow, Developmental Biology","imageUrl":"http://cancer.stanford.edu/profiles/viewImage?facultyId=21246&type=small&showNoImage","displayName":"Xuecai Ge","firstName":"Xuecai","href":"http://med.stanford.edu/profiles/postdocs/researcher/Xuecai_Ge","researchInterest":"I am interested in how the Hedgehog signaling transduction is regulated, and how the mis-regulation of Hedgehog pathway leads to human diseases such as Medulloblastoma."}]}