Cancer Institute A national cancer institute
designated cancer center

C. Garrison Fathman

Publication Details

  • GRAIL: a unique mediator of CD4 T-lymphocyte unresponsiveness FEBS JOURNAL Whiting, C. C., Su, L. L., Lin, J. T., Fathman, C. G. 2011; 278 (1): 47-58


    GRAIL (gene related to anergy in lymphocytes, also known as RNF128), an ubiquitin-protein ligase (E3), utilizes a unique single transmembrane protein with a split-function motif, and is an important gatekeeper of T-cell unresponsiveness. Although it may play a role in other CD4 T-cell functions including activation, survival and differentiation, GRAIL is most well characterized as a negative regulator of T-cell receptor responsiveness and cytokine production. Here, we review the recent literature on this remarkable E3 in the regulation of human and mouse CD4 T-cell unresponsiveness.

    View details for DOI 10.1111/j.1742-4658.2010.07922.x

    View details for Web of Science ID 000285249100006

    View details for PubMedID 21078124

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