Cancer Institute A national cancer institute
designated cancer center

Yueh-hsiu Chien

Publication Details

  • Ligand recognition during thymic development and gamma delta T cell function specification SEMINARS IN IMMUNOLOGY Meyer, C., Zeng, X., Chien, Y. 2010; 22 (4): 207-213


    gammadelta T cells develop in the thymus before entering the periphery. Recent work suggests that thymic development does little to constrain gammadelta T cell antigen specificities, but instead determines their effector fate. When triggered through the T cell receptor, ligand-naïve gammadelta T cells produce IL-17, ligand-experienced cells make IFN-gamma and those that are strongly self-reactive make IL-4. Importantly, gammadelta T cells are able to make cytokines immediately upon TCR engagement. These characteristics allow gammadelta T cells to initiate an acute inflammatory response to pathogens and to host antigens revealed by injury. These advances warrant a fresh look at how gammadelta T cells may function in the immune system.

    View details for DOI 10.1016/j.smim.2010.04.002

    View details for Web of Science ID 000280383400004

    View details for PubMedID 20430644

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