Cancer Institute A national cancer institute
designated cancer center

Rajat Rohatgi

Publication Details

  • The ciliary membrane CURRENT OPINION IN CELL BIOLOGY Rohatgi, R., Snell, W. J. 2010; 22 (4): 541-546


    Cilia and flagella are important organizing centers for signaling in both development and disease. A key to their function is a poorly characterized barrier at their base that allows the protein and lipid composition of the ciliary membrane to be distinct from that of the plasma membrane. We review current models of ciliary membrane biogenesis, highlighting several structures, including the ciliary necklace and ciliary pocket, that appear during biogenesis and that likely contribute to the barrier. The regulated movement of membrane proteins and lipids across this barrier is central to the sensory function of these organelles.

    View details for DOI 10.1016/

    View details for Web of Science ID 000280945500017

    View details for PubMedID 20399632

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