Cancer Institute A national cancer institute
designated cancer center

Jeffrey Axelrod

Publication Details

  • Planar Cell Polarity Signaling: The Developing Cell's Compass COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY Vladar, E. K., Antic, D., Axelrod, J. D. 2009; 1 (3)


    Cells of many tissues acquire cellular asymmetry to execute their physiologic functions. The planar cell polarity system, first characterized in Drosophila, is important for many of these events. Studies in Drosophila suggest that an upstream system breaks cellular symmetry by converting tissue gradients to subcellular asymmetry, whereas a downstream system amplifies subcellular asymmetry and communicates polarity between cells. In this review, we discuss apparent similarities and differences in the mechanism that controls PCP as it has been adapted to a broad variety of morphological cellular asymmetries in various organisms.

    View details for DOI 10.1101/cshperspect.a002964

    View details for Web of Science ID 000279879100006

    View details for PubMedID 20066108

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