Cancer Institute A national cancer institute
designated cancer center

Christopher H. Contag

Publication Details

  • Nanoparticle Formation of Organic Compounds With Retained Biological Activity JOURNAL OF PHARMACEUTICAL SCIENCES Jacobson, G. B., Shinde, R., McCullough, R. L., Cheng, N. J., Creasman, A., Beyene, A., Hickerson, R. P., Quan, C., Turner, C., Kaspar, R. L., Contag, C. H., Zare, R. N. 2010; 99 (6): 2750-2755


    Many pharmaceuticals are formulated as powders to aid drug delivery. A major problem is how to produce powders having high purity, controlled morphology, and retained bioactivity. We demonstrate the use of supercritical carbon dioxide as an antisolvent for meeting this need for two model drug systems, quercetin, a sparingly soluble antioxidant, and short interfering RNA (siRNA), which can silence genes. In both cases we achieve retention of bioactivity as well as a narrow particle size distribution in which the particles are free of impurities.

    View details for DOI 10.1002/jps.22035

    View details for Web of Science ID 000278241800022

    View details for PubMedID 20039390

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