Cancer Institute A national cancer institute
designated cancer center

Dean W. Felsher

Publication Details

  • Myc and a Cdk2 senescence switch NATURE CELL BIOLOGY van Riggelen, J., Felsher, D. W. 2010; 12 (1): 7-9


    Cdk2 has been shown to have an unanticipated role in suppressing Myc-induced senescence. This has implications for how c-Myc overcomes failsafe mechanisms to induce tumorigenesis and suggests that the inhibition of Cdk2 may have therapeutic efficacy in the treatment of cancer.

    View details for DOI 10.1038/ncb0110-7

    View details for Web of Science ID 000272973800006

    View details for PubMedID 20027199

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