Cancer Institute A national cancer institute
designated cancer center

Howard Y. Chang

Publication Details

  • Anatomic Demarcation of Cells: Genes to Patterns SCIENCE Chang, H. Y. 2009; 326 (5957): 1206-1207

    Abstract:

    An organizing principle of the diverse cell types in multicellular organisms is their anatomic location. In turn, anatomic location is patterned by the positional identities of cells along developmental axes. Recent progress in functional genomics and chromatin biology illustrates how cells use specific gene expression programs to encode location. Dynamic chromatin states of key genes, notably the Hox loci, serve as the internal representation in cells of their positional identity within the animal.

    View details for DOI 10.1126/science.1175686

    View details for Web of Science ID 000272117900032

    View details for PubMedID 19965461

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