Cancer Institute A national cancer institute
designated cancer center

Christopher H. Contag

Publication Details

  • Guided by the light: visualizing biomolecular processes in living animals with bioluminescence CURRENT OPINION IN CHEMICAL BIOLOGY Prescher, J. A., Contag, C. H. 2010; 14 (1): 80-89


    Bioluminescence imaging (BLI) exploits the light-emitting properties of luciferase enzymes for monitoring cells and biomolecular processes in living subjects. Luciferases can be incorporated into a variety of non-luminescent hosts and used to track cells, visualize gene expression, and analyze collections of biomolecules. This article highlights recent applications of BLI to studies of mammalian biology, along with the development of novel bioluminescent probes to 'see' cells and molecules in action. Collectively, these efforts are expanding our understanding of living systems and shedding light on the molecular underpinnings of disease.

    View details for DOI 10.1016/j.cbpa.2009.11.001

    View details for Web of Science ID 000274946700013

    View details for PubMedID 19962933

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