Cancer Institute A national cancer institute
designated cancer center

Roeland Nusse

Publication Details

  • Towards an integrated view of Wnt signaling in development DEVELOPMENT van Amerongen, R., Nusse, R. 2009; 136 (19): 3205-3214

    Abstract:

    Wnt signaling is crucial for embryonic development in all animal species studied to date. The interaction between Wnt proteins and cell surface receptors can result in a variety of intracellular responses. A key remaining question is how these specific responses take shape in the context of a complex, multicellular organism. Recent studies suggest that we have to revise some of our most basic ideas about Wnt signal transduction. Rather than thinking about Wnt signaling in terms of distinct, linear, cellular signaling pathways, we propose a novel view that considers the integration of multiple, often simultaneous, inputs at the level of both Wnt-receptor binding and the downstream, intracellular response.

    View details for DOI 10.1242/dev.033910

    View details for Web of Science ID 000269568400001

    View details for PubMedID 19736321

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