Cancer Institute A national cancer institute
designated cancer center

Matthew Bogyo

Publication Details

  • Rab35 Controls Actin Bundling by Recruiting Fascin as an Effector Protein SCIENCE Zhang, J., Fonovic, M., Suyama, K., Bogyo, M., Scott, M. P. 2009; 325 (5945): 1250-1254


    Actin filaments are key components of the eukaryotic cytoskeleton that provide mechanical structure and generate forces during cell shape changes, growth, and migration. Actin filaments are dynamically assembled into higher-order structures at specified locations to regulate diverse functions. The Rab family of small guanosine triphosphatases is evolutionarily conserved and mediates intracellular vesicle trafficking. We found that Rab35 regulates the assembly of actin filaments during bristle development in Drosophila and filopodia formation in cultured cells. These effects were mediated by the actin-bundling protein fascin, which directly associated with active Rab35. Targeting Rab35 to the outer mitochondrial membrane triggered actin recruitment, demonstrating a role for an intracellular trafficking protein in localized actin assembly.

    View details for DOI 10.1126/science.1174921

    View details for Web of Science ID 000269523200039

    View details for PubMedID 19729655

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