Cancer Institute A national cancer institute
designated cancer center

Jeffrey Axelrod

Publication Details

  • Progress and challenges in understanding planar cell polarity signaling SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY Axelrod, J. D. 2009; 20 (8): 964-971


    During development, epithelial cells in some tissues acquire a polarity orthogonal to their apical-basal axis. This polarity, referred to as planar cell polarity (PCP), or tissue polarity, is essential for the normal physiological function of many epithelia. Early studies of PCP focused on insect epithelia (Lawrence, 1966 [1]), and the earliest genetic analyses were carried out in Drosophila (Held et al., 1986; Gubb and Garcia-Bellido, 1982 [2,3]). Indeed, most of our mechanistic understanding of PCP derives from the ongoing use of Drosophila as a model system. However, a range of medically important developmental defects and physiological processes are under the control of PCP mechanisms that appear to be at least partially conserved, driving considerable interest in studying PCP both in Drosophila and in vertebrate model systems. Here, I present a model of the PCP signaling mechanism based on studies in Drosophila. I highlight two areas in which our understanding is deficient, and which lead to current confusion in the literature. Future studies that shed light on these areas will substantially enhance our understanding of the fascinating yet challenging problem of understanding the mechanisms that generate PCP.

    View details for DOI 10.1016/j.semcdb.2009.08.001

    View details for Web of Science ID 000274300800012

    View details for PubMedID 19665570

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