Cancer Institute A national cancer institute
designated cancer center

Atul Butte

Publication Details

  • Systematic Evaluation of Drug-Disease Relationships to Identify Leads for Novel Drug Uses CLINICAL PHARMACOLOGY & THERAPEUTICS Chiang, A. P., Butte, A. J. 2009; 86 (5): 507-510


    Drug repositioning refers to the discovery of alternative uses for drugs--uses that are different from that for which the drugs were originally intended. One challenge in this effort lies in choosing the indication for which a drug of interest could be prospectively tested. We systematically evaluated a drug treatment-based view of diseases in order to address this challenge. Suggestions for novel drug uses were generated using a "guilt by association" approach. When compared with a control group of drug uses, the suggested novel drug uses generated by this approach were significantly enriched with respect to previous and ongoing clinical trials.

    View details for DOI 10.1038/clpt.2009.103

    View details for Web of Science ID 000271186000018

    View details for PubMedID 19571805

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