Cancer Institute A national cancer institute
designated cancer center

Robert Negrin

Publication Details

  • Natural Killer Cells in Allogeneic Transplantation: Effect on Engraftment, Graft- versus-Tumor, and Graft-versus-Host Responses BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION Gill, S., Olson, J. A., Negrin, R. S. 2009; 15 (7): 765-776


    Natural killer (NK) cells are effectors of the innate immune system and recognize cells transformed by viruses or neoplasia. Their response to "missing self" signals was described 3 decades ago, but the recent discovery of a panoply of activating receptors has made it clear that NK cell reactivity arises from a combination of inhibitory and activating signals. Successful clinical exploitation of NK cell reactivity was demonstrated in allogeneic transplantation for acute myelogenous leukemia from HLA-haploidentical donors when matched donors were not available. Multiple clinical studies have since attempted to use NK reactivity in the setting of both HLA-matched and -mismatched transplantation, with varying results. This review summarizes the heterogeneous clinical results and explains them based on a succinct description of NK cell biology.

    View details for DOI 10.1016/j.bbmt.2009.01.019

    View details for Web of Science ID 000267588300001

    View details for PubMedID 19539207

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