Cancer Institute A national cancer institute
designated cancer center

Yueh-hsiu Chien

Publication Details

  • Thymic maturation determines gamma delta T cell function, but not their antigen specificities CURRENT OPINION IN IMMUNOLOGY Jensen, K. D., Chien, Y. 2009; 21 (2): 140-145


    gammadelta T cells contribute uniquely to host immune defense, but how they do so remains unclear. Recent work suggests that thymic selection does little to constrain gammadelta T cell antigen specificities, but instead determines their effector fate. When triggered through the T cell receptor, ligand-experienced cells make IFNgamma, whereas ligand-naïve gammadelta T cells produce IL-17, a major initiator of inflammation. These advances warrant a fresh look at how gammadelta T cells may function in the immune system.

    View details for DOI 10.1016/j.coi.2009.02.008

    View details for Web of Science ID 000266223400005

    View details for PubMedID 19321327

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