Cancer Institute A national cancer institute
designated cancer center

Dean W. Felsher

Publication Details

  • SPECT and PET Imaging of EGF Receptors with Site-Specifically Labeled EGF and Dimeric EGF BIOCONJUGATE CHEMISTRY Levashova, Z., Backer, M. V., Horng, G., Felsher, D., Backer, J. M., Blankenberg, F. G. 2009; 20 (4): 742-749

    Abstract:

    We describe a new generation of tracers for molecular imaging of the cell surface receptors for epidermal growth factor (EGF). These receptors play a key role in the progression of many tumors and are major drug development targets. Our tracers are based on a recombinant human EGF expressed with a cysteine-containing tag that enables facile site-specific radiolabeling with (99m)Tc for single photon emission computed tomography or site-specific conjugation of (64)Cu PEGylated chelators for positron emission tomography. These tracers retain EGF activities in vitro and display selective and highly specific focal uptake in tumors in vivo. We expect that nuclear imaging of EGF receptors with these tracers will be useful for clinical diagnosis, therapeutic monitoring, and development of new drugs and treatment regimens.

    View details for DOI 10.1021/bc800443w

    View details for Web of Science ID 000265284200013

    View details for PubMedID 19320434

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