Cancer Institute A national cancer institute
designated cancer center

Jeffrey Axelrod

Publication Details

  • Cell packing influences planar cell polarity signaling PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Ma, D., Amonlirdviman, K., Raffard, R. L., Abate, A., Tomlin, C. J., Axelrod, J. D. 2008; 105 (48): 18800-18805


    Some epithelial cells display asymmetry along an axis orthogonal to the apical-basal axis, referred to as planar cell polarity (PCP). A Frizzled-mediated feedback loop coordinates PCP between neighboring cells, and the cadherin Fat transduces a global directional cue that orients PCP with respect to the tissue axes. The feedback loop can propagate polarity across clones of cells that lack the global directional signal, although this polarity propagation is error prone. Here, we show that, in the Drosophila wing, a combination of cell geometry and nonautonomous signaling at clone boundaries determines the correct or incorrect polarity propagation in clones that lack Fat mediated global directional information. Pattern elements, such as veins, and sporadic occurrences of irregular geometry are obstacles to polarity propagation. Hence, in the wild type, broad distribution of the global directional cue combines with a local feedback mechanism to overcome irregularities in cell packing geometry during PCP signaling.

    View details for DOI 10.1073/pnas.0808868105

    View details for Web of Science ID 000261489100036

    View details for PubMedID 19022903

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