Cancer Institute A national cancer institute
designated cancer center

Matthew Bogyo

Publication Details

  • Activity-based probes as a tool for functional proteomic analysis of proteases EXPERT REVIEW OF PROTEOMICS Fonovic, M., Bogyo, M. 2008; 5 (5): 721-730


    Traditional proteomics methodology allows global analysis of protein abundance but does not provide information on the regulation of protein activity. Proteases, in particular, are known for their multilayered post-translational activity regulation that can lead to a significant difference between protease abundance levels and their enzyme activity. To address these issues, the field of activity-based proteomics has been established in order to characterize protein activity and monitor the functional regulation of enzymes in complex proteomes. In this review, we present structural features of activity-based probes for proteases and discuss their applications in proteomic profiling of various catalytic classes of proteases.

    View details for DOI 10.1586/14789450.5.5.721

    View details for Web of Science ID 000260701000013

    View details for PubMedID 18937562

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