Cancer Institute A national cancer institute
designated cancer center

Matthew Bogyo

Publication Details

  • Friend or Foe? Turning a Host Defense Protein Into a Pathogen's Accomplice CHEMISTRY & BIOLOGY Shen, A., Bogyo, M. 2008; 15 (9): 879-880


    Cystatins are cysteine protease inhibitors that are at the front-line of defense against pathogens that secrete proteases as virulence factors. In this issue, Vincents et al. (2008) reveal how the bacterial protease IdeS from Streptococcus pyogenes hijacks normal cystatin C function to convert it into a cofactor that enhances proteolytic destruction of host-defense antibodies.

    View details for DOI 10.1016/j.chembiol.2008.09.001

    View details for Web of Science ID 000259918200002

    View details for PubMedID 18804024

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