Cancer Institute A national cancer institute
designated cancer center

Philip W. Lavori

Publication Details

  • Developing and Testing Adaptive Treatment Strategies Using Substance-Induced Psychosis as an Example PSYCHOPHARMACOLOGY BULLETIN Dawson, R., Green, A. I., Drake, R. E., McGlashan, T. H., Schanzer, B., Lavori, P. W. 2008; 41 (3): 51-67


    Decisions concerning treatment changes pervade the management of chronic psychiatric disorders that resist definitive cure, yet empirical evidence for the comparative clinical effectiveness of treatment strategies remains underdeveloped. In this paper we exploit the example of psychosis following substance use to illustrate some new developments in clinical trials design that can provide the most solid evidence base for defining successful strategies. The intent is to explore the strengths and limitations of the methodological approach through a meaningful clinical example, with an emphasis on concepts and issues. Both methodology and clinical science are overviewed.

    View details for Web of Science ID 000207792700004

    View details for PubMedID 18779776

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