Cancer Institute A national cancer institute
designated cancer center

Roeland Nusse

Publication Details

  • Alternative Wnt Signaling Is Initiated by Distinct Receptors SCIENCE SIGNALING van Amerongen, R., Mikels, A., Nusse, R. 2008; 1 (35)

    Abstract:

    An unanswered question in the field of signal transduction research is how different signaling pathways are activated with strict specificity in a temporally and spatially controlled manner. Because extracellular ligands and membrane receptors constitute the first signaling modalities for most pathways, selectivity in ligand-receptor binding likely dictates the outcome of downstream signaling events. Unfortunately, possible complexities underlying ligand-receptor interactions are often overlooked. Here, we discuss basic principles of signal transduction initiated at the cell membrane, with the Wnt pathway, which harbors a multitude of ligands and receptors, as an example.

    View details for DOI 10.1126/scisignal.135re9

    View details for Web of Science ID 000207496300005

    View details for PubMedID 18765832

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