Cancer Institute A national cancer institute
designated cancer center

Atul Butte

Publication Details

  • INSULIN SIGNAL-TRANSDUCTION PATHWAYS TRENDS IN ENDOCRINOLOGY AND METABOLISM Quon, M. J., Butte, A. J., Taylor, S. I. 1994; 5 (9): 369-376

    Abstract:

    Insulin initiates its pleiotropic effects by activating the insulin receptor tyrosine kinase to phosphorylate several intracellular proteins. Recent studies have demonstrated that phosphotyrosine residues bind specifically to proteins that contain src homology 2 (SH2) domains, and that this interaction mediates the regulation of multiple intracellular signaling pathways. This article reviews recent progress in elucidating the detailed pathways that lead from the insulin receptor to the ultimate biologic actions of insulin.

    View details for Web of Science ID A1994PX53400003

    View details for PubMedID 18407232

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