Cancer Institute A national cancer institute
designated cancer center

Margaret T. Fuller

Publication Details

  • Asymmetric inheritance of mother versus daughter centrosome in stem cell division SCIENCE Yamashita, Y. M., Mahowald, A. P., Perlin, J. R., Fuller, M. T. 2007; 315 (5811): 518-521

    Abstract:

    Adult stem cells often divide asymmetrically to produce one self-renewed stem cell and one differentiating cell, thus maintaining both populations. The asymmetric outcome of stem cell divisions can be specified by an oriented spindle and local self-renewal signals from the stem cell niche. Here we show that developmentally programmed asymmetric behavior and inheritance of mother and daughter centrosomes underlies the stereotyped spindle orientation and asymmetric outcome of stem cell divisions in the Drosophila male germ line. The mother centrosome remains anchored near the niche while the daughter centrosome migrates to the opposite side of the cell before spindle formation.

    View details for DOI 10.1126/science.1134910

    View details for Web of Science ID 000243726600048

    View details for PubMedID 17255513

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