Cancer Institute A national cancer institute
designated cancer center

Jeffrey Axelrod

Publication Details

  • The Drosophila casein kinase I epsilon/delta Discs overgrown promotes cell survival via activation of DIAP1 expression DEVELOPMENTAL BIOLOGY Guan, J., Li, H., Rogulja, A., Axelrod, J. D., Cadigan, K. M. 2007; 303 (1): 16-28


    The proper number of cells in developing tissues is achieved by coordinating cell division with apoptosis. In Drosophila, the adult wing is derived from wing imaginal discs, which undergo a period of growth and proliferation during larval stages without much programmed cell death. In this report, we demonstrate that the Drosophila casein kinase Iepsilon/delta, known as Discs overgrown (Dco), is required for maintaining this low level of apoptosis. Expression of dco can suppress the apoptotic activity of Head involution defective (Hid) in the developing eye. Loss of dco in the wing disc results in a dramatic reduction in expression of the caspase inhibitor DIAP1 and a concomitant activation of caspases. The regulation of DIAP1 by Dco occurs by a post-transcriptional mechanism that is independent of hid. Mutant clones of dco are considerably smaller than controls even when apoptosis is inhibited, suggesting that Dco promotes cell division/growth in addition to its role in cell survival. The dco phenotype cannot be explained by defects Wingless (Wg) signaling. We propose that Dco coordinates tissue size by stimulating cell division/growth and blocking apoptosis via activation of DIAP1 expression.

    View details for DOI 10.1016/j.ydbio.2006.10.028

    View details for Web of Science ID 000244542800002

    View details for PubMedID 17134692

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