Cancer Institute A national cancer institute
designated cancer center

Robert Negrin

Publication Details

  • Role of naturally arising regulatory T cells in hematopoietic cell transplantation BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION Nguyen, V. H., Zeiser, R., Negrin, R. S. 2006; 12 (10): 995-1009

    Abstract:

    Naturally arising CD4(+)CD25(+) regulatory T cells (Tregs) have the potential to suppress aberrant immune responses and to regulate peripheral T-cell homeostasis. In murine models of bone marrow transplantation, Tregs promote donor bone marrow engraftment and decrease the incidence and severity of graft-versus-host-disease without abrogating the beneficial graft-versus-tumor immunologic effect. These findings, in concert with observations that Tregs in mice and humans share phenotypic and functional characteristics, have led to active investigations into the use of these cells to decrease complications associated with human hematopoietic cell transplantation. Early human studies suggest that an imbalance of Tregs and effector T cells may contribute to the development of graft-versus-host-disease. However, the mechanisms of immunoregulation, in particular the allorecognition properties of Tregs, their effects on and interaction with other immune cells, and their sites of suppressive activity, are not well understood. In this review, we discuss the current knowledge of Treg biology and the potential therapeutic strategies and barriers of Treg immunotherapy in human hematopoietic cell transplantation.

    View details for DOI 10.1016/j.bbmt.2006.04.009

    View details for Web of Science ID 000241305900001

    View details for PubMedID 17084366

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