Cleo Lee
Publication Details
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MicroRNA regulation of oncolytic herpes simplex virus-1 for selective killing of prostate cancer cells.
Clin Cancer Res. 2009; (16): 5126-35
Advanced castration-resistant prostate cancer, for which there are few treatment options, remains one of the leading causes of cancer death. MicroRNAs (miRNA) have provided a new opportunity for more stringent regulation of tumor-specific viral replication. The purpose of this study was to provide a proof-of-principle that miRNA-regulated oncolytic herpes simplex virus-1 (HSV-1) virus can selectively target cancer cells with reduced toxicity to normal tissues.
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