Cancer Institute A national cancer institute
designated cancer center

James L. Zehnder, M.D.

Publication Details

  • Gene expression profile of idiopathic thrombocytopenic purpura (ITP) PEDIATRIC BLOOD & CANCER Sood, R., Wong, W., Jeng, M., Zehnder, J. L. 2006; 47 (5): 675-677


    To search for novel mechanisms that contribute to the pathophysiology of idiopathic thrombocytopenic purpura (ITP), we determined the whole blood gene expression profile in five ITP patients and five control samples. Using DNA microarrays that contained 24,473 unique putative genes, we found 176 cDNAs that were strongly correlated with ITP. These included a cluster of interferon-regulated genes and TLR7, as well many less-well characterized genes which are candidates for further study. We believe this approach is likely to yield new insights into our understanding of the molecular pathophysiology of ITP.

    View details for DOI 10.1002/pbc.20981

    View details for Web of Science ID 000240405600010

    View details for PubMedID 16933260

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