Cancer Institute A national cancer institute
designated cancer center

Daniel Bloch

Publication Details

  • A combined superiority and non-inferiority approach to multiple endpoints in clinical trials STATISTICS IN MEDICINE Bloch, D. A., Lai, T. L., Su, Z., Tubert-Bitter, P. 2007; 26 (6): 1193-1207


    Treatment comparisons in clinical trials often involve multiple endpoints. By making use of bootstrap tests, we develop a new non-parametric approach to multiple-endpoint testing that can be used to demonstrate non-inferiority of a new treatment for all endpoints and superiority for some endpoint when it is compared to an active control. It is shown that this approach does not incur a large multiplicity cost in sample size to achieve reasonable power and that it can incorporate complex dependencies in the multivariate distributions of all outcome variables for the two treatments via bootstrap resampling.

    View details for DOI 10.1002/sim.2611

    View details for Web of Science ID 000244903400002

    View details for PubMedID 16791905

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