Cancer Institute A national cancer institute
designated cancer center

Christopher H. Contag

Publication Details

  • Releasable luciferin-transporter conjugates: Tools for the real-time analysis of cellular uptake and release JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Jones, L. R., Goun, E. A., Shinde, R., Rothbard, J. B., Contag, C. H., Wender, P. A. 2006; 128 (20): 6526-6527

    Abstract:

    The design, synthesis, and evaluation of conjugates of arginine-rich transporters and luciferin are described that release luciferin only after entry into cells that are stably transfected with luciferase. Each molecule of free luciferin that is released after entry generates a photon that can be measured allowing for real-time quantification of uptake and release in cells. The process provides a method to assay uptake and release of free luciferin as a function of variations in the releasable linker and in the transporter.

    View details for DOI 10.1021/ja0586283

    View details for Web of Science ID 000237590500002

    View details for PubMedID 16704230

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