Cancer Institute A national cancer institute
designated cancer center

Michael Link

Publication Details

  • CHILDHOOD MALIGNANT NON-HODGKIN LYMPHOMAS OF UNCOMMON HISTOLOGY LEUKEMIA Ribeiro, R. C., Pui, C. H., Murphy, S. B., Shuster, J. J., HVIZDALA, E. V., FALLETTA, J., Link, M. P., Sullivan, M. P., Pick, T. E., Sandlund, J. T., Fairclough, D., Crist, W. M., Berard, C. W. 1992; 6 (8): 761-765


    Uncommon histologies were identified in 36 of 1336 cases (2.7%) of newly diagnosed childhood non-Hodgkin lymphoma (NHL). Seventeen cases were classified as follicular (six cases as mixed small and large cell, nine as large cell, and two as small non-cleaved cell) and 19 cases as diffuse (18 cases as mixed small and large cell, and one as small cell lymphocytic). The follicular pattern group included a preponderance of male patients; the median age at diagnosis was 11.7 years. These children presented primarily with low-stage disease involving lymph nodes or tonsils. All patients except one achieved complete remission and remain disease-free for 11 months to 18.8 years (actuarial 5-year event-free survival, 94%). The group with diffuse histologies was similar in sex ratio, age at diagnosis (median = 12.1 years), and nodal involvement, but tended to have more advanced-stage disease. Moreover, only 14 of 19 (74%) children with diffuse intermediate-grade histologies are alive in continuous complete remission (actuarial 5-year event-free survival, 70%). These results suggest that follicular pattern childhood NHL has an excellent prognosis, whereas cases with diffuse intermediate-grade histology are prognostically similar to those with diffuse high-grade histologies.

    View details for Web of Science ID A1992JJ50700003

    View details for PubMedID 1640726

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