Cancer Institute A national cancer institute
designated cancer center

Atul Butte

Publication Details

  • Creation and implications of a phenome-genome network NATURE BIOTECHNOLOGY Butte, A. J., Kohane, I. S. 2006; 24 (1): 55-62


    Although gene and protein measurements are increasing in quantity and comprehensiveness, they do not characterize a sample's entire phenotype in an environmental or experimental context. Here we comprehensively consider associations between components of phenotype, genotype and environment to identify genes that may govern phenotype and responses to the environment. Context from the annotations of gene expression data sets in the Gene Expression Omnibus is represented using the Unified Medical Language System, a compendium of biomedical vocabularies with nearly 1-million concepts. After showing how data sets can be clustered by annotative concepts, we find a network of relations between phenotypic, disease, environmental and experimental contexts as well as genes with differential expression associated with these concepts. We identify novel genes related to concepts such as aging. Comprehensively identifying genes related to phenotype and environment is a step toward the Human Phenome Project.

    View details for DOI 10.1038/nbt1150

    View details for Web of Science ID 000234555800024

    View details for PubMedID 16404398

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