Cancer Institute A national cancer institute
designated cancer center

Matthew Bogyo

Publication Details

  • A general solid phase method for the preparation of diverse azapeptide probes directed against cysteine proteases ORGANIC LETTERS Kato, D., Verhelst, S. H., Sexton, K. B., Bogyo, M. 2005; 7 (25): 5649-5652


    [chemical reaction: see text]. A solid phase approach is presented for the synthesis of azapeptide inhibitors and activity based probes (ABPs) for cysteine proteases. This synthetic method allows the incorporation of diverse reactive warheads linked to different peptide recognition elements. Application of this method to the synthesis of a series of caspase probes is described.

    View details for DOI 10.1021/ol052275v

    View details for Web of Science ID 000233778300027

    View details for PubMedID 16321013

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