Cancer Institute A national cancer institute
designated cancer center

Yueh-hsiu Chien

Publication Details

  • A population of murine gamma delta T cells that recognize an inducible MHC class lb molecule SCIENCE Crowley, M. P., Fahrer, A. M., Baumgarth, N., Hampl, J., Gutgemann, I., Teyton, L., Chien, Y. H. 2000; 287 (5451): 314-316


    Although gammadelta T cells are implicated in regulating immune responses, gammadelta T cell-ligand pairs that could mediate such regulatory functions have not been identified. Here, the expression of the major histocompatibility complex (MHC) class Ib T22 and the closely related T10 molecules is shown to be activation-induced, and they confer specificity to about 0.4% of the gammadelta T cells in normal mice. Thus, the increased expression of T22 and/or T10 might trigger immunoregulatory gammadelta T cells during immune responses. Furthermore, the fast on-rates and slow off-rates that characterize this receptor/ligand interaction would compensate for the low ligand stability and suggest a high threshold for gammadelta T cell activation.

    View details for Web of Science ID 000084769600043

    View details for PubMedID 10634788

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