Cancer Institute A national cancer institute
designated cancer center

Matthew Bogyo

Publication Details

  • Proteomics meets microbiology: technical advances in the global mapping of protein expression and function CELLULAR MICROBIOLOGY Phillips, C. I., Bogyo, M. 2005; 7 (8): 1061-1076

    Abstract:

    The availability of complete genome sequences for a large number of pathogenic organisms has opened the door for large-scale proteomic studies to dissect both protein expression/regulation and function. This review highlights key proteomic methods including two-dimensional gel electrophoresis, reference mapping, protein expression profiling and recent advances in gel-free separation techniques that have made a significant impact on the resolution of complex proteomes. In addition, we highlight recent developments in the field of chemical proteomics, a branch of proteomics aimed at functionally profiling a proteome. These techniques include the development of activity-based probes and activity-based protein profiling methods as well as the use of synthetic small molecule libraries to screen for pharmacological tools to perturb basic biological processes. This review will focus on the applications of these technologies to the field of microbiology.

    View details for DOI 10.1111/j.1462-5822.2005.00554.x

    View details for Web of Science ID 000230343300002

    View details for PubMedID 16008574

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