Cancer Institute A national cancer institute
designated cancer center

Dean W. Felsher

Publication Details

  • Tumor dormancy and MYC inactivation: Pushing cancer to the brink of normalcy CANCER RESEARCH Shachaf, C. M., Felsher, D. W. 2005; 65 (11): 4471-4474

    Abstract:

    Upon MYC inactivation, tumors variously undergo proliferative arrest, cellular differentiation, and apoptosis and in some cases, apparently permanently revoking tumorigenesis. In liver tumor cells, we recently showed that MYC inactivation uncovers stem cell properties and triggers differentiation, but in this case, their neoplastic properties are restorable by MYC reactivation. Thus, whereas oncogene inactivation can push cancer to the brink of normalcy, some cells retain the latent capacity to turn cancerous again, arguing that they may exist in a state of tumor dormancy.

    View details for Web of Science ID 000229407800002

    View details for PubMedID 15930260

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