Cancer Institute A national cancer institute
designated cancer center

Michael Link

Publication Details

  • ISOCHROMOSOMES IN CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA - A COLLABORATIVE STUDY OF 83 CASES BLOOD Pui, C. H., Carroll, A. J., Raimondi, S. C., Schell, M. J., Head, D. R., Shuster, J. J., Crist, W. M., Borowitz, M. J., Link, M. P., Behm, F. G., Steuber, C. P., Land, V. J. 1992; 79 (9): 2384-2391


    Cytogenetic analysis of leukemic cells from 2,805 children with newly diagnosed acute lymphoblastic leukemia (ALL) identified 83 cases (3%) that had a stemline with at least one isochromosome. The i(9q) was present in 28 (1%), the i(17q) in 23 (0.8%), and the i(7q) in 23 (0.8%). Other isochromosomes--i(21q), i(6p), i(1q), i(8q), or i(Xq)--were found in only 12 cases (0.4%). The isochromosome cases were more likely than were other ALL cases to have a pre-B immunophenotype (38% v 25%, P = .02) and leukemic cell hyperdiploidy greater than 50 (37% v 24%, P = .02); five cases had both features. The i(9q) was associated with age greater than 10 years (P less than .05) and the pre-B immunophenotype (P = .05); both the i(17q) and i(7q) had high frequencies of hyperdiploidy greater than 50 (P less than .0001 and P = .05, respectively). The t(1;19)(q23;p13) was a common feature (23%) in cases with the i(9q), i(7q), i(6p), or i(1q). These findings establish the i(9q), i(17q), and i(7q) as nonrandom chromosomal abnormalities in ALL. The prognostic significance of the presence of isochromosome(s) remains to be determined.

    View details for Web of Science ID A1992HW88400027

    View details for PubMedID 1571550

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