Cancer Institute A national cancer institute
designated cancer center

Jeffrey Axelrod

Publication Details

  • Mathematical modeling of planar cell polarity to understand domineering nonautonomy SCIENCE Amonlirdviman, K., Khare, N. A., Tree, D. R., Chen, W. S., Axelrod, J. D., Tomlin, C. J. 2005; 307 (5708): 423-426


    Planar cell polarity (PCP) signaling generates subcellular asymmetry along an axis orthogonal to the epithelial apical-basal axis. Through a poorly understood mechanism, cell clones that have mutations in some PCP signaling components, including some, but not all, alleles of the receptor frizzled, cause polarity disruptions of neighboring wild-type cells, a phenomenon referred to as domineering nonautonomy. Here, a contact-dependent signaling hypothesis, derived from experimental results, is shown by reaction-diffusion, partial differential equation modeling and simulation to fully reproduce PCP phenotypes, including domineering nonautonomy, in the Drosophila wing. The sufficiency of this model and the experimental validation of model predictions reveal how specific protein-protein interactions produce autonomy or domineering nonautonomy.

    View details for DOI 10.1126/science.1105471

    View details for Web of Science ID 000226492300047

    View details for PubMedID 15662015

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